Trimethylsilylpyrazoles as Novel Inhibitors of p38 MAP Kinase: A New Use of Silicon Bioisosteres in Medicinal Chemistry

Autor: Julie B. H. Warneck, John Gary Montana, Richard Conroy, John S. Mills, Louise M. Walsh, Graham A. Showell, David John Miller, Matthew J. Barnes, Pooni Parminder Kaur
Rok vydání: 2007
Předmět:
Lipopolysaccharides
Models
Molecular
Chemical Phenomena
Silicon
Chemistry
Pharmaceutical
p38 mitogen-activated protein kinases
Clinical Biochemistry
Pharmaceutical Science
chemistry.chemical_element
In Vitro Techniques
Crystallography
X-Ray
Biochemistry
Chemical synthesis
p38 Mitogen-Activated Protein Kinases
chemistry.chemical_compound
Mice
Drug Discovery
Animals
Humans
Enzyme Inhibitors
Protein kinase A
Molecular Biology
Tumor necrosis factor α
biology
Chemistry
Physical
Tumor Necrosis Factor-alpha
Chemistry
Organic Chemistry
Silicon Compounds
technology
industry
and agriculture
Organic Silicon Compounds
Stereoisomerism
General Medicine
Combinatorial chemistry
Mitogen-activated protein kinase
Microsomes
Liver
biology.protein
Molecular Medicine
Pyrazoles
Indicators and Reagents
Bioisostere
Zdroj: ChemInform. 38
ISSN: 1522-2667
0931-7597
Popis: The synthesis, physicochemical properties and pharmacological profiles of two novel silicon-containing p38 MAP kinase inhibitors are described.
Databáze: OpenAIRE
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