Assessment of In vitro antioxidant, antibacterial and immune activation potentials of aqueous and ethanol extracts of Phyllanthus niruri
| Autor: | Mahmood Ameen Abdulla, Zahra A. Amin, Suhailah W Qadir, Mohammed A. Alshawsh, Hapipah Mohd Ali |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Staphylococcus aureus
Phyllanthus Antioxidant DPPH medicine.medical_treatment Flavonoid Antioxidants Streptococcus agalactiae chemistry.chemical_compound Adjuvants Immunologic Picrates medicine Humans Benzothiazoles IC50 Cell Proliferation chemistry.chemical_classification Nutrition and Dietetics ABTS Bacteria biology Traditional medicine Plant Extracts Chemistry Biphenyl Compounds Biological activity biology.organism_classification Anti-Bacterial Agents Thiazoles Biochemistry Leukocytes Mononuclear Sulfonic Acids Antibacterial activity Agronomy and Crop Science Food Science Biotechnology |
| Zdroj: | Journal of the Science of Food and Agriculture. 92:1874-1877 |
| ISSN: | 0022-5142 |
| DOI: | 10.1002/jsfa.5554 |
| Popis: | BACKGROUND: Recently much attention has been paid to biologically active plants because of their low production cost and fewer adverse effects compared with chemical drugs. In the present investigation the bioactivity of Phyllanthus niruri ethanol and aqueous extracts was evaluated invitro. RESULTS: The ethanol extract of P. niruri showed a high level of flavonoid content (123.9 ± 0.002 mg g −1 ), while the aqueous extract showed the highest 2,2-diphenyl-1-picrylhydrazyl (DPPH; IC50 6.85 ± 1.80 µmol L −1 )a nd 2,2 � -azino-bis(3ethylbenzothiazoline-6-sulfonicacid)(ABTS;46.44 ±0.53 µmol L −1 )freeradicalscavengingactivitieswithhighphenolcontent (376 ± 0.02 mg g −1 ) and elevated levels of ferric reducing antioxidant power (FRAP; 23883 ± 0.019 mmol g −1 ) with excellent antibacterial activity against Staphylococcus aureus (20 mm inhibition zone) and Streptococcus agalactiae (12 mm inhibition zone),respectively,inadditiontothebestimmuneactivationpotentialofhumanperipheralbloodmononuclearcells(450.5%). CONCLUSIONS: It is clear from our results that both extracts of P. niruri has excellent bioactivity roles via elevated levels of antibacterial, antioxidant and percentage of peripheral blood mononuclear cell proliferation, which could lead to the development of medications for clinical use. c � 2012 Society of Chemical Industry |
| Databáze: | OpenAIRE |
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