A new application of the Rotterdam Diabetic Foot Study Test Battery: grading pedal sensory loss to predict the risk of foot ulceration
| Autor: | Manuel Castro Cabezas, J. Henk Coert, Willem D. Rinkel |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Male
medicine.medical_specialty Endocrinology Diabetes and Metabolism 030209 endocrinology & metabolism Cohort Studies 03 medical and health sciences 0302 clinical medicine Endocrinology Risk Factors Diabetes mellitus Sensation Internal Medicine medicine Humans 030212 general & internal medicine Prospective Studies Grading (education) Foot Ulcer Aged business.industry Incidence (epidemiology) Incidence Sensory loss General Medicine Middle Aged medicine.disease Diabetic foot Diabetic Foot Physical therapy Observational study Female business Foot (unit) |
| Zdroj: | Diabetes research and clinical practice. 175 |
| ISSN: | 1872-8227 |
| Popis: | To assess the relationship between the degree of loss of foot sensation at baseline and incidence of foot ulceration (DFU).Diabetic patients (n = 416) participating in the observational Rotterdam Diabetic Foot (RDF) Study were followed prospectively (median 955.5 days (IQR, 841.5-1121)). Subjects underwent sensory testing of the feet (39-item RDF Study Test Battery) at baseline and were assessed regarding incident DFU. Seven groups of incremental degree of sensory loss were distinguished, according to the RDF-39 sum score. Kaplan-Meier and regression analyses were used to determine the independent hazard of baseline variables for new DFU.40 participants developed DFUs. The mean incident rate of new-onset ulceration from study start was 4.5 (95%CI: 3.3 to 6.1) per 100 person-years, which increased significantly from 0 to 67.70 in the seven groups (p 0.0005). Predictors for DFUs were higher RDF-39 score (aHR: 1.173, p 0.0005) and kidney function (aHR: 1.022, p = 0.016). Prior DFU suggests increased mortality risk.The degree of sensory loss at baseline was associated with progression to DFU during follow-up. Grading the loss of sensation using the RDF Study Test Battery may result in a more precise risk stratification compared to the use of the 10 g monofilament according to current guidelines. |
| Databáze: | OpenAIRE |
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