Mortality risk after herpes zoster infection in end-stage renal disease patients
| Autor: | Jake E. Turrentine, Stephanie L Baer, N. Stanley Nahman, John H Ahn, Mufaddal Kheda, Jennifer L. Waller, Rhonda E Colombo |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
medicine.medical_specialty
Population 030232 urology & nephrology herpes zoster Disease End stage renal disease 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Risk of mortality risk factors United States Renal Data System education Transplantation education.field_of_study Proportional hazards model business.industry Hazard ratio mortality Nephrology dialysis Zoster vaccine Diagnosis code Infection business medicine.drug |
| Zdroj: | Clinical Kidney Journal |
| ISSN: | 2048-8513 2048-8505 |
| DOI: | 10.1093/ckj/sfy058 |
| Popis: | Background End-stage renal disease (ESRD) patients have increased risk of developing herpes zoster (zoster) compared with the general population, but mortality risk is unknown. We assessed the risk of mortality in hospitalized ESRD patients with a diagnosis of zoster from the inpatient hospital files (as opposed to outpatient records) of the United States Renal Data System. Methods This study analyzed incident ESRD patients from 2006 to 2009. Based on an International Classification of Diseases, Ninth Revision, Clinical Modification diagnosis code of zoster infection, we determined 2-year mortality following an inpatient diagnosis. Cox proportional hazards models were used to examine the association of mortality and zoster, when controlling for demographic and other clinical risk factors. Results Zoster was diagnosed in 2784 patients, 51% of whom died within 2 years, with a mean time to death of 8.1 months. Patients who died were more likely to be white and older, score higher on the Charlson Comorbidity Index (CCI) and have other clinical diagnoses besides CCI. Increased risk of death within 2 years was associated with older age (adjusted hazard ratio 1.03), malnutrition (1.31), bacteremia/septicemia (1.16) and increasing CCI (1.10). Zoster vaccine was administered to 27 patients, but the small number precluded analysis of its impact. Conclusions Mortality in ESRD patients with an inpatient zoster diagnosis is increased with older age and higher severity of clinical comorbidities. The role of zoster vaccination on mortality in this population remains to be defined. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|