Reducing urinary oxalate by simultaneous using Sankol herbal drop with oxalate-degrading bacteria
| Autor: | Rouhi Afkari, Habib Ghaznavi, Fereshteh Heidari Tajabadi, Mohammad Mehdi Feizabadi, Mohammad Bokaeian, Soroosh Dabiri, Mohsen Taheri |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Microbiology (medical)
Normal diet Probiotic bacteria lcsh:QR1-502 01 natural sciences Microbiology lcsh:Microbiology Oxalate law.invention chemistry.chemical_compound Probiotic law Lactobacillus 0502 economics and business medicine Sankol drop Food science 0101 mathematics Bifidobacterium Hyperoxaluria Ethanol biology Chemistry Oxalate degrading bacteria 010102 general mathematics 05 social sciences Herbal medicine biology.organism_classification Antispasmodic Original Article 050203 business & management Bacteria medicine.drug |
| Zdroj: | Iranian Journal of Microbiology Iranian Journal of Microbiology, Vol 11, Iss 6 (2020) |
| ISSN: | 2008-4447 2008-3289 |
| Popis: | Background and Objectives: Oxalate degrading bacteria and herbal extracts are new strategy for reducing hyperoxaluria. In Iranian traditional medicine, Sankol oral drop is widely used as an antispasmodic drug to reduce stones from urinary tract. This study aimed to evaluate the synergistic effect of oxalate-degrading bacteria and Sankol oral drop in reducing urinary oxalate in rat model. Materials and Methods: Several bacterial strains, including Lactobacillus (4), Bifidobacterium (2) and L. paracasei (2) (very strong in degrading oxalate in vitro) were used in this study. Male Wistar rats were divided into 6 groups (n = 6). The rats of Group I received normal diet and drinking water + 60% ethanol (positive group). Groups II (negative group), III, IV, V, and VI rats received diet containing ethylene glycol (3%) for 30 days. Groups III rats received Sankol with minimum concentration (7.5 ml/kg/b.w), Group IV rats received Sankol with maximum concentration (9 ml/kg/b.w), Group V rats received Sankol with minimum concentration + probiotic, and Group VI rats received Sankol with maximum concentration + probiotic for 30 days. Results: Treatment with Sankol (maximum concentration) and oxalate-degrading probiotic bacteria significantly reduced urinary oxalate (P = .0001). At the end of treatment period, rats in groups II (negative control) showed a high score of CaOx crystal, while rats in VI groups did not show any CaOx crystal. Conclusion: This is the first study on the simultaneous use of Sankol herbal drop and oxalate-degrading probiotic bacteria that showed a significant reduction in urinary oxalate. |
| Databáze: | OpenAIRE |
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