Monoclonal antibodies against CD54 (ICAM-1) and CD11a (LFA-1) prevent and inhibit endotoxin-induced uveitis
| Autor: | Robert B. Nussenblatt, Scott M. Whitcup, Naofumi Hikita, Manabu Mochizuki, Masayuki Miyasaka, Takuya Tamatani, M Shirao, Chi-Chao Chan |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
medicine.drug_class
Lymphocyte Cell Count Inflammation CD11a Eye Monoclonal antibody Uveitis Cellular and Molecular Neuroscience medicine Animals ICAM-1 biology Cell adhesion molecule business.industry Antibodies Monoclonal Intercellular Adhesion Molecule-1 medicine.disease Lymphocyte Function-Associated Antigen-1 Sensory Systems Rats Endotoxins Ophthalmology medicine.anatomical_structure Rats Inbred Lew Immunology biology.protein Female medicine.symptom Antibody business |
| Zdroj: | Experimental Eye Research. 60:597-601 |
| ISSN: | 0014-4835 |
| DOI: | 10.1016/s0014-4835(05)80001-6 |
| Popis: | We studied the effect of monoclonal antibodies (mAbs) against CD54 (intercellular adhesion molecule-1; ICAM-1) and CD11a (lymphocyte function-associated antigen-1; LFA-1) on the prevention and treatment of endotoxin-induced uveitis (EIU). When treated at the time of endotoxin injection the mean number of inflammatory cells infiltrating the eye +/- S.E.M. on histologic sections was 469.2 +/- 51.9 for controls, 13.8 +/- 2.6 for rats receiving anti-ICAM-1 mAb (P0.0001), and 195.8 +/- 48.8 for rats receiving anti-LFA-1 mAb (P = 0.0003). When treated after the start of inflammatory disease, the mean number of infiltrating inflammatory cells +/- S.E.M. was 273.0 +/- 30.7 for controls, 6.4 +/- 1.7 for rats receiving anti-ICAM-1 mAb (P0.0001), and 54.2 +/- 7.6 for rats receiving anti-LFA-1 mAb (P0.0001). The mean number of cells per milliliter of aqueous humor +/- S.E.M. was 1867.6 +/- 321.8 for controls, 21.7 +/- 5.3 for rats receiving anti-ICAM-1 mAb (P0.0001), and 295.1 +/- 71.2 for rats receiving anti-LFA-1 mAb (P0.0001). MAbs against ICAM-1 and LFA-1 significantly inhibited the development of EIU and were effective in treating clinically evident ocular inflammatory disease. |
| Databáze: | OpenAIRE |
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