Smart triblock dendritic unimolecular micelles as pioneering nanomaterials: Advancement pertaining to architecture and biomedical applications
| Autor: | Pramod Kumar, Prajakta Tambe, Kishore M. Paknikar, Virendra Gajbhiye |
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| Rok vydání: | 2019 |
| Předmět: |
Dendrimers
0303 health sciences Materials science Polymers Cancer therapy Pharmaceutical Science Nanotechnology 02 engineering and technology 021001 nanoscience & nanotechnology Micelle Theranostic Nanomedicine Nanostructures Nanomaterials 03 medical and health sciences Drug Delivery Systems Delayed-Action Preparations Neoplasms Drug delivery Animals Humans 0210 nano-technology Micelles 030304 developmental biology |
| Zdroj: | Journal of Controlled Release. 299:64-89 |
| ISSN: | 0168-3659 |
| DOI: | 10.1016/j.jconrel.2019.02.026 |
| Popis: | Recent interest in triblock dendritic unimolecular micelles has opened a new spectrum for its ubiquitous application in biomedical sciences specially drug delivery. Unimolecular dendritic micelles have brought significant attention due to their high encapsulation efficiency, high-functionality, and site specific confinement capabilities. During the last decade, the number of publications in this field has increased drastically, reinforced by the fact that several clinical trials are underway using micelles for drug delivery. This review unveils the most recent advancement on the synthesis and applications of cutting-edge unimolecular micelles using dendritic and star-shaped molecules emphasizing on triblock copolymers. The major biomedical applications covered in this manuscript are drug/gene/bio-macromolecules delivery to the site of interest, as contrast agents in bio-imaging, and cancer targeted theranostics using stimuli-responsive mechanism. |
| Databáze: | OpenAIRE |
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