Sensory modulation of fasciculation discharge frequency
| Autor: | Antónia Turkman, Michael Swash, Mamede de Carvalho |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Adult
Male 0301 basic medicine Physiology Stimulation 030105 genetics & heredity Fasciculation Vibration Lower motor neuron Muscular Atrophy Spinal 03 medical and health sciences Cellular and Molecular Neuroscience 0302 clinical medicine Physiology (medical) medicine Humans Amyotrophic lateral sclerosis Muscle Skeletal Aged Motor Neurons Electromyography business.industry Amyotrophic Lateral Sclerosis Spinal muscular atrophy Middle Aged Hand medicine.disease Electric Stimulation Peripheral medicine.anatomical_structure Female Radial Nerve Neurology (clinical) medicine.symptom business Neuroscience 030217 neurology & neurosurgery Benign fasciculation syndrome Sensory nerve |
| Zdroj: | Muscle & Nerve. 59:688-693 |
| ISSN: | 1097-4598 0148-639X |
| Popis: | Introduction Fasciculations are a marker for the diagnosis of amyotrophic lateral sclerosis (ALS) and reflect increased lower motor neuron (LMN) excitability. Methods We investigated modulation of fasciculation frequency in the first dorsal interosseous (FDI) muscle of the right hand following peripheral sensory nerve electrical stimulation, and vibration over the muscle-tendon region (50 and 100 Hz), in patients with ALS, spinal muscular atrophy, and benign fasciculation syndrome. FDI muscles of ALS patients were classified by the presence or absence of neurogenic changes on needle electromyography. Results Both sensory nerve electrical stimulation and vibration significantly increased the frequency of fasciculations in neurogenic FDI muscles of ALS patients, but not in the remaining groups. Discussion Our results favour increased excitability of LMNs when affected by the disease process in ALS. We found that some fasciculations originating in these neurons in ALS are susceptible to modulation by sensory input. Muscle Nerve 59:688-693, 2019. |
| Databáze: | OpenAIRE |
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