Influence of the Preoperative C-Reactive Protein-to-Albumin Ratio on Survival and Recurrence in Patients With Esophageal Cancer
| Autor: | Ayako Tamagawa, Yukio Maezawa, Kentaro Hara, Yosuke Atsumi, Kazuki Kano, Masakatsu Numata, Masaaki Murakawa, Takashi Oshima, Toru Aoyama, Norio Yukawa, Keisuke Kazama, Keisuke Komori, Hiroshi Tamagawa, Munetaka Masuda, Yasushi Rino |
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| Rok vydání: | 2020 |
| Předmět: |
Adult
Male Cancer Research medicine.medical_specialty Multivariate analysis Esophageal Neoplasms Kaplan-Meier Estimate Gastroenterology 03 medical and health sciences 0302 clinical medicine Internal medicine Biomarkers Tumor medicine Humans In patient Risk factor Serum Albumin Aged Retrospective Studies Aged 80 and over Receiver operating characteristic biology business.industry C-reactive protein Albumin Cancer General Medicine Middle Aged Esophageal cancer Prognosis medicine.disease C-Reactive Protein Oncology 030220 oncology & carcinogenesis Preoperative Period Carcinoma Squamous Cell biology.protein Female Neoplasm Recurrence Local business |
| Zdroj: | Anticancer Research. 40:2365-2371 |
| ISSN: | 1791-7530 0250-7005 |
| Popis: | Background Several immune-inflammatory markers are associated with cancer progression. The purpose of the present study was to clarify the influence of the preoperative C-reactive protein-to-albumin ratio (CRP/ALB ratio) on survival of patients with esophageal cancer and recurrence after curative resection. Patients and methods The preoperative CRP/ALB ratio was evaluated in 122 patients who underwent radical resection for esophageal cancer from 2005 to 2018. The correlations between the CRP/ALB ratio and cancer-specific overall (OS), recurrence-free (RFS) survival and the clinicopathological status were analyzed. Results The optimal cut-off value of the CRP/ALB ratio determined using receiver operating characteristic curve analysis was 0.04. Patients were divided into two groups based on this cut-off value: the low CRP/ALB group (n=59) and the high CRP/ALB group (n=50). The OS rate at 5 years after surgery was significantly lower in the group with high CRP/ALB at 40.5% whilst it was 63.5% in the low CRP/ALB group (p=0.005). The corresponding RFS rates at 5 years after surgery were 32.5% and 48.3%, respectively, which was a statistically significant difference (p=0.007). A multivariate analysis showed that a high CRP/ALB ratio was a significant independent risk factor for poorer cancer-specific OS and RFS. Conclusion The preoperative CRP/ALB ratio was a strong prognostic marker for patients with esophageal cancer. The surgical strategy, including procedure and perioperative care should be carefully planned for patients with a high CRP/ALB ratio. |
| Databáze: | OpenAIRE |
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