Proteome analysis to study signal transduction of G protein-coupled receptors
| Autor: | Karin Mörl, Franka Pluder, Annette G. Beck-Sickinger |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
Pharmacology
Proteomics Metabotropic glutamate receptor 5 Protein Array Analysis Computational biology Biology Receptors G-Protein-Coupled Drug development Biochemistry Stable isotope labeling by amino acids in cell culture Proteome Animals Humans Pharmacology (medical) Signal transduction Receptor Function (biology) G protein-coupled receptor Signal Transduction |
| Zdroj: | Pharmacologytherapeutics. 112(1) |
| ISSN: | 0163-7258 |
| Popis: | G protein-coupled receptors (GPCR) play an important role in drug development. Although many classical signal transduction pathways have been elucidated, more and more cross-talk to other cascades, e.g. MAP-kinase have been reported. In order to identify the overall function of receptor stimulation in a specific cell type or under certain conditions proteome analysis has been shown to be a very successful and powerful approach. Here, we will summarize the current state of the art of proteome analysis applied to GPCR. |
| Databáze: | OpenAIRE |
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