Chimeric Antigen Receptor Engineering: A Right Step in the Evolution of Adoptive Cellular Immunotherapy
| Autor: | Kayley Trotter, Lauren Littlefield, Venu Madhav Konala, Fabio Grizzi, Paul L. Hermonat, Adair Reidy, Breeanna Musgrove, Leonardo Mirandola, Rakhshanda Layeequr Rahman, Luke N. D'Cunha, Maurizio Chiriva-Internati, Saba Radhi, Jose A. Figueroa, Alejandro Figueroa, Everardo Cobos, Nicholas D'Cunha, Natallia Suvorava, Marjorie R. Jenkins, Amardeep Aulakh |
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| Rok vydání: | 2015 |
| Předmět: |
Adoptive cell transfer
Recombinant Fusion Proteins T-Lymphocytes medicine.medical_treatment Immunology Receptors Antigen T-Cell Immunotherapy Dendritic cell Biology Immunotherapy Adoptive Chimeric antigen receptor Antigen Cancer immunotherapy Cancer stem cell Neoplasms medicine Animals Humans Immunology and Allergy Cancer/testis antigens Genetic Engineering |
| Zdroj: | International Reviews of Immunology. 34:154-187 |
| ISSN: | 1563-5244 0883-0185 |
| Popis: | Cancer immunotherapy comprises different therapeutic strategies that exploit the use of distinct components of the immune system, with the common goal of specifically targeting and eradicating neoplastic cells. These varied approaches include the use of specific monoclonal antibodies, checkpoint inhibitors, cytokines, therapeutic cancer vaccines and cellular anticancer strategies such as activated dendritic cell (DC) vaccines, tumor-infiltrating lymphocytes (TILs) and, more recently, genetically engineered T cells. Each one of these approaches has demonstrated promise, but their generalized success has been hindered by the paucity of specific tumor targets resulting in suboptimal tumor responses and unpredictable toxicities. This review will concentrate on recent advances on the use of engineered T cells for adoptive cellular immunotherapy (ACI) in cancer. |
| Databáze: | OpenAIRE |
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