Oral contraceptives and mortality trends from thromboembolism in the United States
| Autor: | R E Markush, D G Seigel |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 1969 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent Arteriosclerosis Population Embolism Coronary Disease Thrombophlebitis Arteriosclerotic heart disease Sinus Thrombosis Intracranial Sex Factors Internal medicine Thromboembolism Mesenteric Vascular Occlusion medicine Humans education Intensive care medicine Venous Embolism education.field_of_study business.industry Mortality rate Racial Groups Age Factors Thrombosis General Medicine Arteries Intracranial Embolism and Thrombosis Middle Aged medicine.disease United Kingdom United States Pulmonary embolism Cardiovascular Diseases Female business Pulmonary Embolism Research Article Contraceptives Oral |
| Popis: | The U.S. mortality trends since 1951 for underlying causes of death related to thrombosis or thromboembolism were evaluated by relative measures to determine whether these increases have occurred in relation to the introduction of oral contraceptives (OC). The analysis was based on published and unpublished data from the U.S. National Center for Health Statistics. Analysis of small groupings of diseases included numbers of deaths since 1960. Larger groupings - 332 420 and 460-8 of the International Classification of Diseases (ICD) 7th Revision included deaths from 1951-1966 for women 15-44 years of age. Methods for determination of relative changes in mortality were listed and 4 comparisons were made: 1) comparison with women during 1957-1961; 2) the same adjusted for corresponding changes in men; 3) the same adjusted for changes between 1951-1956 and 1957-1961; and 4) with men during 1962-1966. On the whole cerebral embolism and thrombosis (ICD 332) decreased in relation to the 4 comparison groups. There have been few deaths from phlebitis and thrombophlebitis of the intracranial venous sinuses in women 15-44 years since 1962. A small relative increase can be shown in arteriosclerotic heart disease (ICD 420) including coronary disease in women age 20-49. The incidence of death from diseases of veins and other diseases of the circulartory system (ICD 460-8) indicated relative increases--phlebitis and thrombophlebitis of the lower extremities increasing consistently from 34 in 1960 to 70 in 1966 phlebitis and thrombophlebitis at other sites increasing from 45 in 1960 to 82 in 1966 pulmonary embolism and infarction increasing from 177 in 1960 to 335 in 1966 and other venous embolism and thrombosis growing from 72 to 141 in the same time frame. The limitations of the method were discussed. Distortion of the 460-8 catagory might occur because of its small size. However results indicate an association of OC with ICD 460-8 while ICD 332 and 420 remain unchanged. These results differ from British mortality rates showing increases in cerebral thrombosis. Differences may be due to the small numbers of cases involved. |
| Databáze: | OpenAIRE |
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