Continuous infusion of methylprednisolone via paediatric parenteral nutrition: A pharmacokinetic animal study
| Autor: | Jean-François Jarrige, Valérie Sautou-Miranda, Jean Chopineau, Christophe Gellis, Régine Minet-Quinard, Nathalie Bleyzac |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Male
Parenteral Nutrition Metabolic Clearance Rate medicine.drug_class Continuous infusion Biological Availability Critical Care and Intensive Care Medicine Random Allocation Pharmacokinetics medicine Animals Humans Infusions Parenteral Animal study Methylprednisolone Hemisuccinate Glucocorticoids Nutrition and Dietetics business.industry Specific Pathogen-Free Organisms Bioavailability Disease Models Animal Drug Combinations Parenteral nutrition Methylprednisolone Anesthesia Corticosteroid Rabbits business Perfusion Chromatography Liquid medicine.drug |
| Zdroj: | Clinical Nutrition. 26:491-497 |
| ISSN: | 0261-5614 |
| Popis: | Summary Background & aims The aim of our study consisted to measure the pharmacokinetic parameters of methylprednisolone administered in a continuous infusion of a paediatric parenteral nutrition mixture for 24 h in the rabbit. Methods Fourteen rabbits were split into two groups and assigned a different administration vehicle (all-in-one or two-in-one nutrition mixture). We used USC PACK* pharmacokinetics software to compare the influence of the composition of the paediatric parenteral nutritional solutions on the values of the pharmacokinetic parameters of methylprednisolone. Results Neither the steady-state plasma concentrations of methylprednisolone hemisuccinate nor the values of the pharmacokinetic parameters of methylprednisolone differed significantly when administered in two-in-one or all-in-one nutrition mixtures. Conclusions The composition of the nutritional medium had no discernable effect on the bioavailability of methylprednisolone. Neither the speed at which the steady-state plasma concentration was reached, nor the values of the pharmacokinetic parameters of methylprednisolone were significantly modified. |
| Databáze: | OpenAIRE |
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