Determination of harpagoside in Harpagophytum procumbens DC tablet’s using analytical method by High Performance Liquid Chromatography
| Autor: | Yris Maria Fonseca-Bazzo, Luiz Alberto Simeoni, Gislane dos Santos Ribeiro, Pérola Oliveira Magalhães, Diegue Henrique Nascimento Martins, Amanda de Assis Carneiro, Dâmaris Silveira |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: | |
| Zdroj: | Eclética Química, Vol 45, Iss 1, Pp 47-55 (2020) Repositório Institucional da UnB Universidade de Brasília (UnB) instacron:UNB |
| ISSN: | 1678-4618 |
| Popis: | The species Harpagophytum procumbens DC. is popularly known as devil’s claw and is widely used because of its anti-inflammatory properties that are attributed to an iridoid glycoside, the harpagoside. This medicinal plant is part of the Brazilian List of Essential Medicines, that is, it was selected and standardized for the resolution of diseases in the Brazilian public health system, SUS, and can be found in several brands. Due to the importance of quality monitoring, the objective of this study was to create and validate a method for identification and quantification of harpagoside in tablets of the devil’s claw, as well as to evaluate the content of this iridoid glycoside in three commercially available brands in Brasília, DF, Brazil. The evaluated parameters in the validation by high performance liquid chromatography (HPLC) were linearity, limits of detection and quantification, precision, selectivity, accuracy and robustness, as required by the Brazilian regulation. The developed and validated method proved satisfactory for the quality control of commercial products that present in this composition the medicinal plant. All the devil’s claw brands presented divergences regarding the quality that can interfere with therapeutics and with safety and efficacy. |
| Databáze: | OpenAIRE |
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