Serotonin 5-HT2 receptors in schizophrenic patients studied by positron emission tomography
| Autor: | Kaoru Kobayashi, Omi Terasaki, Takeshi Sassa, Kazutoshi Suzuki, Yasuhiko Sudo, Yasuhiro Someya, Yukio Tateno, Yoshiro Okubo, Toru Michi, Eisuke Matsushima, Tetsuya Suhara, Masaomi Iyo, Osamu Inoue |
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| Rok vydání: | 2000 |
| Předmět: |
Adult
medicine.medical_specialty General Biochemistry Genetics and Molecular Biology Dopamine receptor D1 Internal medicine medicine Humans General Pharmacology Toxicology and Pharmaceutics Receptor Prefrontal cortex 5-HT receptor Cerebral Cortex Carbon Isotopes medicine.diagnostic_test business.industry General Medicine medicine.disease Cortex (botany) Endocrinology Spiperone Schizophrenia Positron emission tomography Receptors Serotonin Serotonin business Tomography Emission-Computed |
| Zdroj: | Life Sciences. 66:2455-2464 |
| ISSN: | 0024-3205 |
| Popis: | Using positron emission tomography (PET) and [11C]N-methylspiperone (NMSP), we examined 5-HT2 receptors in the cortex of schizophrenic patients in whom we previously observed decereased prefrontal D1 receptor binding. The subjects were 10 neuroleptic-naive schizophrenic patients, 7 schizophrenic patients who were drug-free but had previously been treated with neuroleptics, and 12 normal controls. A non-significant trend towards decreased prefrontal [11C]NMSP binding was observed in the neuroleptic-treated patients, suggesting a possible effect of previous neuroleptic treatment on the alteration in cortical 5-HT2 function. However, the neuroleptic-naive patients showed no noticeable difference in cortical [11C]NMSP binding compared to controls. Our results do not rule out the role of 5-HT2 function as a crucial site of therapeutic activity of schizophrenia, but they do suggest that cortical 5-HT2 receptors might not be primarily involved in the pathophysiology of schizophrenia. |
| Databáze: | OpenAIRE |
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