Solution structure of a thrombin binding aptamer complex with a non-planar platinum(ii ) compound
| Autor: | Bo-Chen Zhu, Juan He, Xiao-Yu Xia, Jingxing Jiang, Wenting Liu, Liu-Yi Liu, Bing-Bing Liang, Hua-Gang Yao, Zhuofeng Ke, Wei Xia, Zong-Wan Mao |
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| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | Chemical Science. 13:8371-8379 |
| ISSN: | 2041-6539 2041-6520 |
| Popis: | A quasi-cross-shaped platinum(II) compound (L′2LPt) with inhibitory activity against thrombin binds the antiparallel two-G-tetrad G-quadruplex TBA. The NMR structure of the Pt–G-quadruplex was solved to reveal this unusual “wall-mounted” binding mode. |
| Databáze: | OpenAIRE |
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