Kinetics of serum cytokines reflect changes in the severity of chronic hepatitis C presenting minimal fibrosis
| Autor: | Marc Bourlière, Dominique Valla, Michelle Martinot-Peignoux, Gady G Katz, Tarik Asselah, Neil H. Shear, Manuela G. Neuman, Jean-Pierre Benhamou, Izabella M. Malkiewicz, Patrick Marcellin, Asma Ibrahim |
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| Rok vydání: | 2002 |
| Předmět: |
Adult
Liver Cirrhosis Male medicine.medical_specialty Pathology Necrosis medicine.medical_treatment Alpha (ethology) Inflammation Hepacivirus Disease Gastroenterology Transforming Growth Factor beta Fibrosis Virology Internal medicine Biopsy medicine Humans Hepatology medicine.diagnostic_test Tumor Necrosis Factor-alpha business.industry Histology Hepatitis C Chronic medicine.disease Kinetics Infectious Diseases Cytokine Liver Disease Progression Female medicine.symptom business |
| Zdroj: | Journal of Viral Hepatitis. 9:134-140 |
| ISSN: | 1365-2893 1352-0504 |
| DOI: | 10.1046/j.1365-2893.2002.00343.x |
| Popis: | Our aims were to measure the kinetics of serum tumour necrosis alpha (TNF-alpha) and transforming growth factor beta (TGF-beta) levels as markers of progression of disease in nontreated chronic hepatitis C virus (HCV)-infected patients with minimal or no fibrosis and minimal histology activity index (HAI) scores. Our study group consisted of 56 patients diagnosed with minimal (1) or no fibrosis (0) and minimal HAI (0-1) on their first biopsy as defined by Knodell and METAVIR scores. We compared their initial (entry of study) cytokine levels with a group of 103 HCV controls with minimal (0-1) to mild fibrosis (0-3) and mild HAI (5.5). Serum TNF-alpha and TGF-beta levels were measured by enzyme-linked-immunosorbent-assay. A significant difference was seen in TNF-alpha levels at baseline in the study group vs. controls. Regardless of their HAI, there was a correlation between TGF-beta and degree of fibrosis. As shown by their biopsies, during the 3 years (from entry to follow up), many of the patients that initially had minimal fibrosis progressed to higher degree of fibrosis. This progression is paralleled by an increase in TGF-beta levels when comparing initial and follow-up levels. In conclusion, serum TNF-alpha reflects the progression of inflammation as seen in liver biopsies and TGF-beta reflects the degree of fibrosis in HCV patients. |
| Databáze: | OpenAIRE |
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