Sirolimus Conversion May Suppress Viral Replication in Hepatitis C Virus-Positive Renal Transplant Candidates
| Autor: | Mahmoud A. Soliman, Amin R. Soliman, S. Khashab, Ahmed Fathy, N. Shaheen |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Adult
Male medicine.medical_specialty Time Factors Hepatitis C virus medicine.medical_treatment Hepacivirus Virus Replication medicine.disease_cause Gastroenterology Chronic allograft nephropathy Internal medicine medicine Humans Prospective Studies Sirolimus Hepatitis Transplantation Drug Substitution business.industry Immunosuppression Hepatitis C Middle Aged Viral Load medicine.disease Kidney Transplantation Treatment Outcome Hepatitis C Virus Positive Cyclosporine Female business Viral load Immunosuppressive Agents medicine.drug |
| Zdroj: | Experimental and Clinical Transplantation. 11:408-411 |
| ISSN: | 2146-8427 1304-0855 |
| DOI: | 10.6002/ect.2013.0017 |
| Popis: | OBJECTIVES Hepatitis C virus in renal transplant recipients is an independent risk factor for sickness and death. It has been shown that one might limit hepatitis C virus progression in liver transplant recipients with sirolimus-based immunosuppression. The mammalian target of rapamycin is an influential molecule for the anti-hepatitis C virus action of interferon. We report our experience with sirolimus conversion in hepatitis C virus-positive patients with chronic allograft nephropathy regarding hepatic and hematologic effects that might affect its future use. MATERIALS AND METHODS Twenty-five patients who had received renal transplants with anti-hepatitis C virus-positive and normal liver function were enrolled. Ten patients had allograft dysfunction because of cyclosporine nephrotoxicity. Sirolimus was initiated at 2 mg/d and adjusted to 6 to 8 ng/mL. Cyclosporine was gradually tapered and then stopped; 15 patients were used as a control group. Sirolimus-related hepatitis was defined as a rise in liver transferases or alkaline phosphatase or bilirubin over twice the upper limit of normal. Viral replication was defined as elevated liver enzymes and increasing viral load and/or biopsy-proven hepatitis C virus active hepatitis. RESULTS After conversion, there was a reduction of hemoglobin and hematocrit. In 1 patient, the immunosuppressive regimen was changed back to cyclosporine owing to anemia and hepatotoxicity leading to prompt return of hematocrit and liver enzymes to their original values. One of 10 antihepatitis C virus-positive patients (10.0%) developed sirolimus-associated hepatotoxicity, compared with 2 patients in the control group (13%). Sirolimus patients showed a significant decrease in the HCV PCR levels from 700 000 to 400 000 IU/mL; P < .001, compared to 680 000 to 660 000 IU/mL in cyclosporine patients; P = NS, with comparable levels of transaminases CONCLUSIONS Our data suggest that sirolimus has the potential to suppress viral replication in hepatitis C virus-positive renal transplant candidates. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|