Circulating levels of apoptotic markers and oxidative stress parameters in women with polycystic ovary syndrome: a case-controlled descriptive study
| Autor: | Tevfik Sabuncu, Nurten Aksoy, Hacer Uyanikoglu, Huseyin Dursun, Hatice Sezen |
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| Rok vydání: | 2017 |
| Předmět: |
Adult
0301 basic medicine medicine.medical_specialty Adolescent endocrine system diseases Health Toxicology and Mutagenesis Clinical Biochemistry Apoptosis Caspase 3 Context (language use) medicine.disease_cause Biochemistry Pathogenesis Young Adult 03 medical and health sciences 0302 clinical medicine Internal medicine Humans Medicine Caspase 7 030219 obstetrics & reproductive medicine business.industry Case-control study nutritional and metabolic diseases Polycystic ovary Caspase 9 female genital diseases and pregnancy complications Oxidative Stress 030104 developmental biology Endocrinology Case-Control Studies Caspases Circulatory system Female business Biomarkers Oxidative stress Polycystic Ovary Syndrome |
| Zdroj: | Biomarkers. :1-5 |
| ISSN: | 1366-5804 1354-750X |
| DOI: | 10.1080/1354750x.2016.1265004 |
| Popis: | Apoptotic dysregulation plays a role in the pathogenesis of polycystic ovary syndrome (PCOS).To evaluate circulatory apoptotic markers and oxidative stress in patients with PCOS.Forty-four women with PCOS, and 44 healthy women as controls were enrolled in the study. Oxidative stress parameters and caspases levels were measured in serum.The caspase 9 level was significantly lower and related with oxidant status in patients with PCOS, while the circulating levels of caspases 3 and 7 were statistically similar in both groups.This study is the first report demonstrating the circulating levels of apoptotic markers and their relationship with oxidant status in PCOS.The circulating caspase 9 and oxidant status might contribute to apoptotic dysregulation in PCOS. |
| Databáze: | OpenAIRE |
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