Blood-brain-barrier in a geriatric population: barrier function in degenerative and vascular dementias

Autor: Lucilla Parnetti, Carla Santucci, Patrizia Mecocci, Gianpaolo Reboldi, I. Gernini, C. Ferri, M. Romagnoli, U. Senin, Alberto Gaiti, Donatella Cadini
Jazyk: angličtina
Rok vydání: 1991
Předmět:
Male
medicine.medical_specialty
Neuropsychological Tests
Blood–brain barrier
cerebrospinal fluid
blood/cerebrospinal fluid
Degenerative disease
Cerebrospinal fluid
Alzheimer Disease
Internal medicine
Albumins
Vascular
medicine
Dementia
Humans
Vascular dementia
CSF albumin
Serum Albumin
Aged
business.industry
Dementia
Vascular
Aged
Albumins
cerebrospinal fluid
Alzheimer Disease
physiopathology
Blood-Brain Barrier
physiology
Dementia
Multi-Infarct
physiopathology
Dementia
physiopathology
Female
Humans
Immunoglobulin G
blood/cerebrospinal fluid
Male
Neuropsychological Tests
Serum Albumin
metabolism
Albumin
General Medicine
medicine.disease
Surgery
medicine.anatomical_structure
Endocrinology
Dementia
Multi-Infarct
Neurology
Blood-Brain Barrier
Immunoglobulin G
physiology
Female
Neurology (clinical)
Alzheimer's disease
physiopathology
business
Popis: Albumin and IgG were determined in serum and cerebrospinal fluid (CSF) of patients with early-onset Alzheimer's disease (AD, n. 13), senile dementia of Alzheimer type (SDAT, n. 33), vascular dementia divided into multi-infarct (MID, n. 9) and probable vascular (PVD, n. 11) dementia. Albumin and IgG ratio and IgG index were calculated. CSF albumin and albumin ratio were significantly higher in MID patients indicating an increased BBB permeability. IgG ratio and IgG index did not show any significant difference among groups. These results do not provide evidence for BBB damage in AD/SDAT, while in MID the increase of CSF albumin and albumin ratio is suggestive of BBB dysfunction.
Databáze: OpenAIRE
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