From perviousness to permeability, modelling and measuring intra-thrombus flow in acute ischemic stroke

Autor: Nerea Arrarte Terreros, Hugo W. A. M. de Jong, Manon L. Tolhuisen, Ed van Bavel, Edwin Bennink, Henk A. Marquering, Ludo F. M. Beenen, Charles B. L. M. Majoie
Přispěvatelé: ACS - Microcirculation, ACS - Atherosclerosis & ischemic syndromes, Amsterdam Neuroscience - Neurovascular Disorders, Graduate School, Radiology and Nuclear Medicine, ACS - Pulmonary hypertension & thrombosis, Amsterdam Gastroenterology Endocrinology Metabolism, Amsterdam Reproduction & Development, Biomedical Engineering and Physics, Amsterdam Reproduction & Development (AR&D)
Rok vydání: 2020
Předmět:
medicine.medical_specialty
Blood flow quantification
Blood velocity
medicine.medical_treatment
0206 medical engineering
Acute ischemic stroke
Flow (psychology)
Biophysics
Biomedical Engineering
02 engineering and technology
Permeability
Brain Ischemia
03 medical and health sciences
0302 clinical medicine
Thrombolytic drug
Internal medicine
medicine
Humans
Orthopedics and Sports Medicine
Dynamic CTA
cardiovascular diseases
Structured model
Thrombus
Ischemic Stroke
Computed tomography angiography
medicine.diagnostic_test
business.industry
Rehabilitation
Thrombosis
Blood flow
medicine.disease
020601 biomedical engineering
Cerebral Angiography
Stroke
medicine.anatomical_structure
Permeability (electromagnetism)
Thrombus permeability
cardiovascular system
Cardiology
business
030217 neurology & neurosurgery
circulatory and respiratory physiology
Artery
Zdroj: UnpayWall
Microsoft Academic Graph
NARCIS
Journal of biomechanics, 111:110001. Elsevier Limited
Journal of Biomechanics
ISSN: 0021-9290
DOI: 10.1016/j.jbiomech.2020.110001
Popis: Thrombus permeability determines blood flow through the occluding thrombus in acute ischemic stroke (AIS) patients. The quantification of thrombus permeability is challenging since it cannot be directly measured nor derived from radiological imaging data. As a proxy of thrombus permeability, thrombus perviousness has been introduced, which assesses the amount of contrast agent that has penetrated the thrombus on single-phase computed tomography angiography (CTA). We present a method to assess thrombus permeability rather than perviousness. We follow a three-step approach: (1) we propose a theoretical channel-like structure model describing the thrombus morphology. Using Darcy’s law, we provide an analytical description of the permeability for this model. According to the channel-like model, permeability depends on the number of channels in the thrombus, the radius of the occluded artery, and the void fraction representing the volume available for the blood to flow; (2) we measure intra-thrombus blood flow and velocity on dynamic CTA; and (3) we combine the analytical model with the dynamic CTA measurements to estimate thrombus permeability. Analysis of dynamic CTA data from 49 AIS patients showed that the median blood velocity in the thrombus was 0.58 (IQR 0.26–1.35) cm/s. The median flow within the thrombus was 3.48 · 10−3 (IQR 1.71 · 10−3–9.21 · 10−3) ml/s. Thrombus permeability was of the order of 10−3–10−5 mm2, depending on the number of channels in the thrombus. The channel-like thrombus model offers an intuitive way of modelling thrombus permeability, which can be of interest when studying the effect of thrombolytic drugs.
Databáze: OpenAIRE
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