Guillain-Barré syndrome: A prospective, population-based incidence and outcome survey
| Autor: | Chiò, A., Cocito, D., Leone, M., Giordana, M. T., Mora, G., Mutani, R., Andrea CALVO, Di Vito, N., Vercellino, M., Bertolotto, A., Bottacchi, E., Mazzini, L., Terreni, A. A., Schiffer, D., Bergamasco, B., Rainero, I., Tribolo, A., Sciolla, R., Mondino, F., Gaviani, P., Monaco, F., Mattei, M., Morgando, E., Sosso, L., Gionco, M., Morino, U., Nobili, M., Appendino, L., Piazza, D., Oddenino, E., Liboni, W., Vaula, G., Ferrari, G., Favero, M., Doriguzzi Bozzo, C., Santamaria, P., Massazza, U., Bollani, E., Villani, A., Conti, R., Balzarini, C., Palermo, M., Vergnano, F., Cordera, S., Buffa, C., Penza, M. T., Fassio, F., Meineri, P., Cognazzo, A., Mocellini, C., Dutto, A., Cucatto, A., Cavestro, C., Troni, W., Corso, G. |
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Adult
Male medicine.medical_specialty Pediatrics Adolescent Population Guillain-Barre Syndrome Severity of Illness Index law.invention Disability Evaluation law Epidemiology Severity of illness Outcome Assessment Health Care medicine Humans Guillain-Barré syndrome prognostic factors Prospective Studies Prospective cohort study education Child Stroke Aged Aged 80 and over education.field_of_study Guillain-Barre syndrome business.industry Incidence (epidemiology) Electrodiagnosis Incidence Infant Recovery of Function Middle Aged medicine.disease Prognosis Intensive care unit United States Surgery Italy Child Preschool Multivariate Analysis Disease Progression Female Neurology (clinical) business Follow-Up Studies |
| Zdroj: | Scopus-Elsevier |
| Popis: | Objective: The authors evaluated the incidence and long-term prognostic factors of Guillain-Barre syndrome (GBS) in a prospective, population-based study. Methods: Patients with GBS diagnosed according to National Institute of Neurological and Communicative Disorders and Stroke criteria in the 2-year period 1995 to 1996 in two Italian regions were prospectively followed up for 2 years after onset of GBS. Results: A total of 120 patients were found, corresponding to a crude annual incidence rate of 1.36/100,000 population (95% CI, 1.13 to 1.63). A total of 7 (5.8%) patients, all but one with axonal or mixed EMG pattern, died acutely within 30 days from the onset of the disease. Acute mortality was due to respiratory involvement and intensive care unit complications. In multivariate analysis, a worse 2-year outcome (Hughes score ≥2) was related to a higher Hughes grade at nadir, axonal or mixed EMG, age ≥50 years, and absence of respiratory infections preceding GBS. The persistence of disability 2 years after the acute phase was related to axonal involvement and a worse status at nadir. Conclusions: After adjustment to US population, the incidence rates for GBS from different countries showed no significant differences. Both acute mortality and long-term disability in GBS seem to be related to an axonal involvement and a Hughes grade ≥2 at nadir. |
| Databáze: | OpenAIRE |
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