Nanovesicles derived from iron oxide nanoparticles–incorporated mesenchymal stem cells for cardiac repair
| Autor: | Han Young Kim, Yeon Woong Choo, Jeong-Kee Yoon, Seuk Young Song, Jonghoon Kim, Ji-Won Hwang, Hun-Jun Park, In Ok Ko, Sung Pil Kwon, Ju-Ro Lee, Mikyung Kang, Ji-Ae Park, Taeghwan Hyeon, Byung-Soo Kim, Kiwon Ban, Hyeok Kim, Bong-Woo Park |
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| Rok vydání: | 2020 |
| Předmět: |
Angiogenesis
Myocardial Infarction Apoptosis Inflammation 02 engineering and technology Exosomes Exosome 03 medical and health sciences chemistry.chemical_compound Fibrosis medicine Humans Health and Medicine Research Articles 030304 developmental biology 0303 health sciences Multidisciplinary Chemistry Mesenchymal stem cell SciAdv r-articles Mesenchymal Stem Cells 021001 nanoscience & nanotechnology medicine.disease Microvesicles Cancer research Magnetic Iron Oxide Nanoparticles medicine.symptom 0210 nano-technology Iron oxide nanoparticles Research Article |
| Zdroj: | Science Advances |
| ISSN: | 2375-2548 |
| Popis: | Increased therapeutic factors and retention of IONP-NVs substantially enhance therapeutic potential for cardiac repair. Because of poor engraftment and safety concerns regarding mesenchymal stem cell (MSC) therapy, MSC-derived exosomes have emerged as an alternative cell-free therapy for myocardial infarction (MI). However, the diffusion of exosomes out of the infarcted heart following injection and the low productivity limit the potential of clinical applications. Here, we developed exosome-mimetic extracellular nanovesicles (NVs) derived from iron oxide nanoparticles (IONPs)–incorporated MSCs (IONP-MSCs). The retention of injected IONP-MSC–derived NVs (IONP-NVs) within the infarcted heart was markedly augmented by magnetic guidance. Furthermore, IONPs significantly increased the levels of therapeutic molecules in IONP-MSCs and IONP-NVs, which can reduce the concern of low exosome productivity. The injection of IONP-NVs into the infarcted heart and magnetic guidance induced an early shift from the inflammation phase to the reparative phase, reduced apoptosis and fibrosis, and enhanced angiogenesis and cardiac function recovery. This approach can enhance the therapeutic potency of an MSC-derived NV therapy. |
| Databáze: | OpenAIRE |
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