Xenopus laevis as a Model Organism for the Study of Spinal Cord Formation, Development, Function and Regeneration
| Autor: | Laura N. Borodinsky |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
ved/biology.organism_classification_rank.species Xenopus Review Neurodegenerative Regenerative Medicine Xenopus laevis Models Spinal cord injury biology axon guidance spinal neuron differentiation Sensory Systems Injury - Trauma medicine.anatomical_structure Spinal Cord Neurological sensorimotor response neural plasticity Spinal Cord Regeneration morphogenetic proteins Physical Injury - Accidents and Adverse Effects Spinal neuron 1.1 Normal biological development and functioning Cognitive Neuroscience Central nervous system Neuroscience (miscellaneous) lcsh:RC321-571 03 medical and health sciences Cellular and Molecular Neuroscience calcium-dependent activity Underpinning research medicine Animals Model organism lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry Traumatic Head and Spine Injury Spinal Cord Injuries Animal ved/biology Regeneration (biology) Neurosciences Stem Cell Research Spinal cord biology.organism_classification medicine.disease spinal cord injury 030104 developmental biology neural tube defects Injury (total) Accidents/Adverse Effects Axon guidance Neuroscience |
| Zdroj: | Frontiers in Neural Circuits Frontiers in Neural Circuits, Vol 11 (2017) Borodinsky, LN. (2017). Xenopus laevis as a model organism for the study of spinal cord formation, development, function and regeneration. Frontiers in Neural Circuits, 11. doi: 10.3389/fncir.2017.00090. UC Davis: Retrieved from: http://www.escholarship.org/uc/item/7nj1z62c |
| ISSN: | 1662-5110 |
| Popis: | © 2017 Borodinsky. The spinal cord is the first central nervous system structure to develop during vertebrate embryogenesis, underscoring its importance to the organism. Because of its early formation, accessibility to the developing spinal cord in amniotes is challenging, often invasive and the experimental approaches amenable to model systems like mammals are limited. In contrast, amphibians, in general and the African-clawed frog Xenopus laevis, in particular, offer model systems in which the formation of the spinal cord, the differentiation of spinal neurons and glia and the establishment of spinal neuron and neuromuscular synapses can be easily investigated with minimal perturbations to the whole organism. The significant advances on gene editing and microscopy along with the recent completion of the Xenopus laevis genome sequencing have reinvigorated the use of this classic model species to elucidate the mechanisms of spinal cord formation, development, function and regeneration. |
| Databáze: | OpenAIRE |
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