Metoclopramide as intermittent and continuous infusions in critically ill patients: a pilot randomized clinical trial
| Autor: | Mostafa Mohammadi, Hossein Khalili, Masoud Ramezani, Masoume Malekolkottab, Anahid Nourian |
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| Rok vydání: | 2017 |
| Předmět: |
Adult
Metoclopramide Continuous infusion Vomiting medicine.medical_treatment Critical Illness Prokinetic agent Pilot Projects Enteral administration Food Intolerance Drug Administration Schedule law.invention 03 medical and health sciences Young Adult 0302 clinical medicine Enteral Nutrition Randomized controlled trial law medicine Humans 030212 general & internal medicine Adverse effect Aged Critically ill business.industry Health Policy 030208 emergency & critical care medicine Nausea Middle Aged Diarrhea Anesthesia Antiemetics medicine.symptom business Energy Intake Gastrointestinal Motility medicine.drug |
| Zdroj: | Journal of comparative effectiveness research. 6(2) |
| ISSN: | 2042-6313 |
| Popis: | Aim: Metoclopramide is commonly used as a prokinetic agent in critically ill patients with enteral feeding intolerance. In this study, noninferiority of metoclopramide as intermittent versus continuous infusion was examined in critically ill patients with enteral feeding intolerance. Methods: Forty critically ill adults patients were assigned to receive metoclopramide as either intermittent (10 mg every 6 h) or continuous (2 mg/h) infusion. Frequency of feeding intolerance and adverse effects of metoclopramide were assessed during 7 days of study. Results: Number of patients with feeding intolerance during different times of the course was not different between the groups. Although not statistically significant, diarrhea and cardiac rhythm were more common in continuous than intermittent infusion group. Conclusion: Continuous and intermittent infusions of metoclopramide showed equivalent effectiveness in critically ill patients. |
| Databáze: | OpenAIRE |
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