Hepatitis B surface antibodies in medical students from a public university in Puebla, Mexico
| Autor: | Gerardo Santos-López, Eduardo Gómez-Conde, Irma Pérez-Contreras, Francisca Sosa-Jurado, Othón Rafael Cruz y López, José Luis Gándara-Ramírez, María Alicia Díaz-Orea, Luis Márquez-Domínguez, María Elena Cárdenas-Perea |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Adult
Male medicine.medical_specialty HBsAg Hepatitis B virus Blood transfusion Students Medical Adolescent Universities medicine.medical_treatment Immunology medicine.disease_cause Organ transplantation 03 medical and health sciences Young Adult 0302 clinical medicine Antigen Seroepidemiologic Studies medicine Immunology and Allergy Humans 030212 general & internal medicine Hepatitis B Antibodies Mexico Pharmacology Hepatitis B Surface Antigens biology business.industry virus diseases Hepatitis B medicine.disease Hepatitis B Core Antigens digestive system diseases Vaccination biology.protein 030211 gastroenterology & hepatology Female Antibody business Research Paper |
| Zdroj: | Human vaccinesimmunotherapeutics. 12(7) |
| ISSN: | 2164-554X |
| Popis: | Although preventable with vaccination, Hepatitis B virus (HBV) infection is a major health concern, with ∼400 million people at risk of developing the chronic form of the disease worldwide. The anti-HBV vaccine consists of a recombinant HBV surface antigen (HBsAg), which induces specific anti-HBs antibodies and confers 95% protection for >20 y. The aim of the present study was to analyze the response to HBV vaccination by measuring anti-HBs antibodies in serum samples from medical students of a public university in Puebla, Mexico. HBV infection markers HBsAg and anti-HBs, were also determined. A total of 201 students were included and vaccination coverage was found at 54%. Overall seropositivity for HBsAg, anti-HBc and anti-HBs determined by ELISA was 0.5%, 1.0% and 47%, respectively. Protective levels of anti-HBs >10 mIU/mL were found in 93.2% of subjects vaccinated with 2 or 3 doses and in 40% of those vaccinated with a single dose; while only 4.8% of unvaccinated subjects were anti-HBs positive. The response to the HBV vaccine was different in each participant, despite similar vaccination scheme. A history of blood transfusion/organ transplant or more than 2 sexual partners was significantly associated with anti-HBc positivity, OR = 399 (p = 0.010) and OR = 19.9 (p = 0.044), respectively. HBV immunization coverage was low in our sample compared with reports from countries with similar HBV prevalence, but anti-HBs in vaccinated individuals were in the expected range. It is important to promote HBV vaccination and awareness among medical students, due to their exposure risk. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|