'Chronic obstructive pulmonary disease and phenotypes: a state-of-the-art.'
| Autor: | Nikolaos Siafakas, Ricardo de Jesus Avendaño Garnica, Yamely Mendez, Victor Botnaru, Alexandru Corlateanu, Yafeng Wang |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Pulmonary and Respiratory Medicine
medicine.medical_specialty COPD business.industry Pulmonary disease Disease Precision medicine medicine.disease Phenotype respiratory tract diseases Pulmonary Disease Chronic Obstructive 03 medical and health sciences FEV1/FVC ratio 0302 clinical medicine 030228 respiratory system Practice Guidelines as Topic medicine Humans Bronchitis 030212 general & internal medicine Precision Medicine Intensive care medicine business Asthma |
| Zdroj: | Pulmonology. 26:95-100 |
| ISSN: | 2531-0437 |
| DOI: | 10.1016/j.pulmoe.2019.10.006 |
| Popis: | Chronic Obstructive Pulmonary Disease (COPD) is a heterogeneous and multisystemic disease with progressive increasing morbidity and mortality. COPD is now widely accepted as a heterogeneous condition with multiple phenotypes and endotypes. This review will discuss the old and new concepts for the different types of COPD phenotypes, as well as the inclusion of them in current guidelines. Phenotypical approach to COPD is having huge impact on everyday practice and changed nonpharmacological and pharmacological management of COPD in last decade. However, phenotypical approach is small step to precision medicine in COPD management in the absence of big, specific and well-designed COPD trials with exact identification of phenotypes for more personalization of the treatment of COPD. |
| Databáze: | OpenAIRE |
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