Dermal dendritic cell number correlates with serum autoantibody titers in Brazilian pemphigus foliaceus patients
| Autor: | Ana Maria Ferreira Roselino, Roberto Silva Costa, Maria Paula do Valle Chiossi |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2004 |
| Předmět: |
Male
Pathology medicine.medical_specialty Physiology Biopsy Immunology Pemphigus foliaceus Biophysics Fogo selvagem Cell Count Autoantibody titers Biochemistry Dendritic cells Lesion Pathogenesis medicine Humans Langerhans cells General Pharmacology Toxicology and Pharmaceutics Anti-CD1a lcsh:QH301-705.5 Autoantibodies Basement membrane lcsh:R5-920 biology medicine.diagnostic_test integumentary system business.industry General Neuroscience Cell Biology General Medicine Dendritic cell medicine.disease Interleukin-12 medicine.anatomical_structure lcsh:Biology (General) Case-Control Studies biology.protein Female Antibody medicine.symptom business lcsh:Medicine (General) Pemphigus |
| Zdroj: | Brazilian Journal of Medical and Biological Research, Vol 37, Iss 3, Pp 337-341 (2004) Brazilian Journal of Medical and Biological Research, Volume: 37, Issue: 3, Pages: 337-341, Published: MAR 2004 |
| ISSN: | 0034-7310 |
| Popis: | Pemphigus foliaceus (PF) is an autoimmune bullous disease endemic in Brazil. Since serum IL-12 is increased in patients with PF and Langerhans cells (LC) produce IL-12, we titrated serum autoantibodies by indirect immunofluorescence, and quantified epidermal dendritic cells, known as LC, and dermal dendritic cells (DC). Biopsies of blistering lesions were obtained from 22 patients, 13 of whom were submitted to biopsy of both injured and of apparently healthy skin. The control groups consisted of skin from 8 cadavers and from 12 women submitted to breast plastic surgery. LC and DC were identified with anti-CD1a antibody and quantified by morphometric analysis. LC number in the lesion and in apparently healthy skin from PF patients was similar to that of both control groups. DC number in the injured skin (median = 0.94 DC/mm basement membrane) was higher than that of the cadaver group (median = 0.13 DC/mm basement membrane). In the 13 patients with biopsies of both injured and apparently healthy skin, LC and DC were present in larger numbers in the lesion. There was a direct correlation between DC number in the lesion of the PF group and serum autoantibody titers. This correlation was not observed for LC number. The increased number of DC in the lesion, as well as its direct correlation with serum autoantibody titers suggest the participation of DC in the pathogenesis of PF. The relationship between increased DC number and IL-12 in PF needs to be clarified. |
| Databáze: | OpenAIRE |
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