A case of HBs antigen negative fulminant hepatitis with IgM antibody to hepatitis B core antigen persisting more than seven years
| Autor: | Mitsuo Suga, Satoshi Yamada, Akira Yachi, Kaori Shibata, Kazuhiro Arima, Toshinori Kodama |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Adult
Male medicine.medical_specialty HBsAg Antigen Liver Function Tests Internal medicine medicine Humans Fulminant hepatitis Hepatitis Chronic Hepatitis Hepatitis B Surface Antigens medicine.diagnostic_test business.industry Gastroenterology virus diseases Hepatology medicine.disease Hepatitis B Virology Hepatitis B Core Antigens digestive system diseases HBcAg HBeAg Immunoglobulin M Immunology business Liver function tests Follow-Up Studies |
| Zdroj: | Gastroenterologia Japonica. 26(5) |
| ISSN: | 0435-1339 |
| Popis: | A 33-year old dentist developed fulminant hepatitis. At admission, a test for IgM antibody to hepatitis B core antigen (IgM anti-HBc) was positive, while tests for HBsAg and HBeAg were negative. He was cured of the disease, but in follow-up examinations from 1983 to 1990 IgM anti-HBc was continuously detected with radioimmunoassay while HBsAg and HBV-DNA were absent in the serum. However, HBcAg was found in a biopsied liver specimen and a small quantity of HBV-DNA was detectable by polymerase chain reaction assay. These observation suggest that the continuous detection of IgM anti-HBc without HBsAg in serum is due to persistent HBV infection and HBV replication in the liver. |
| Databáze: | OpenAIRE |
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