FGF2 Attenuates Neural Cell Death via Suppressing Autophagy after Rat Mild Traumatic Brain Injury
| Autor: | Yilan Hu, Yun Tong, Xiaojie Wei, Xiao-Jun Fu, Chonghui Tang, Yudong Shan, Mengdan Chen, Xinlong Xu, Zhanjian Fang |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
lcsh:Internal medicine Programmed cell death Necrosis Article Subject Traumatic brain injury Angiogenesis Neuroprotection 03 medical and health sciences 0302 clinical medicine Neurotrophic factors medicine lcsh:RC31-1245 Molecular Biology integumentary system business.industry Neurogenesis Autophagy Cell Biology medicine.disease 030104 developmental biology Anesthesia embryonic structures medicine.symptom business Neuroscience 030217 neurology & neurosurgery Research Article |
| Zdroj: | Stem Cells International Stem Cells International, Vol 2017 (2017) |
| ISSN: | 1687-9678 1687-966X |
| Popis: | Traumatic brain injury (TBI) can lead to physical and cognitive deficits, which are caused by the secondary injury process. Effective pharmacotherapies for TBI patients are still lacking. Fibroblast growth factor-2 (FGF2) is an important neurotrophic factor that can stimulate neurogenesis and angiogenesis and has been shown to have neuroprotective effects after brain insults. Previous studies indicated that FGF2’s neuroprotective effects might be related to its function of regulating autophagy. The present study investigated FGF2’s beneficial effects in the early stage of rat mild TBI and the underlying mechanisms. One hundred and forty-four rats were used for creating controlled cortical impact (CCI) models to simulate the pathological damage after TBI. Our results indicated that pretreatment of FGF2 played a neuroprotective role in the early stage of rat mild TBI through alleviating brain edema, reducing neurological deficits, preventing tissue loss, and increasing the number of surviving neurons in injured cortex and the ipsilateral hippocampus. FGF2 could also protect cells from various forms of death such as apoptosis or necrosis through inhibition of autophagy. Finally, autophagy activator rapamycin could abolish the protective effects of FGF2. This study extended our understanding of FGF2’s neuroprotective effects and shed lights on the pharmacological therapy after TBI. |
| Databáze: | OpenAIRE |
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