Monoclonal antibodies to bovine growth hormone potentiate effects of the hormone on somatomedin C levels and growth of hypophysectomized rats
| Autor: | Janet D. Cottingham, Margaret Daniels, Michael Wallis, Roger Aston, Keith P. Ray |
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| Rok vydání: | 1987 |
| Předmět: |
Male
medicine.medical_specialty animal structures medicine.drug_class Biophysics Stimulation Body weight Monoclonal antibody Biochemistry Somatomedins Internal medicine medicine Animals Bovine somatotropin Insulin-Like Growth Factor I Molecular Biology Hypophysectomy biology Chemistry Body Weight Antibodies Monoclonal Rats Inbred Strains Long-term potentiation Cell Biology Somatomedin Rats Kinetics Endocrinology Growth Hormone biology.protein Cattle Antibody hormones hormone substitutes and hormone antagonists Hormone |
| Zdroj: | Biochemical and Biophysical Research Communications. 149:187-193 |
| ISSN: | 0006-291X |
| DOI: | 10.1016/0006-291x(87)91622-6 |
| Popis: | Bovine growth hormone (50 μg/day) elevated somatomedin C levels in plasma of hypophysectomized rats: the effect was seen 12 h after the first injection and was sustained throughout a 7-day treatment period. When monoclonal antibodies to bovine growth hormone were administered with the hormone the stimulation of somatomedin C levels was markedly enhanced, as were effects on body weight. Each one of a panel of 7 monoclonal antibodies potentiated the actions of the hormone on growth and somatomedin C levels, though the extent and pattern of potentiation varied considerably from one antibody to another. Effects on growth and somatomedin C levels correlated fairly well, though there were some discrepancies. |
| Databáze: | OpenAIRE |
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