Prescription switching: Rationales and risks
| Autor: | Richard Gledhill, Damian Greene, Derek J. Rosario, James S.A. Green, Tim Appanna, Paula Allchorne, Mike Kirby, Patrick Davey |
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| Rok vydání: | 2019 |
| Předmět: |
Drug
Drug Substitution business.industry media_common.quotation_subject General Medicine 030204 cardiovascular system & hematology Drug Prescriptions Drug switching Gonadotropin-Releasing Hormone 03 medical and health sciences 0302 clinical medicine Drug class Risk analysis (engineering) General practice Drugs Generic Humans Medicine Lower cost 030212 general & internal medicine Hydroxymethylglutaryl-CoA Reductase Inhibitors Medical prescription business media_common |
| Zdroj: | International Journal of Clinical Practice. 74 |
| ISSN: | 1742-1241 1368-5031 |
| DOI: | 10.1111/ijcp.13429 |
| Popis: | Background Therapeutic drug switching is commonplace across a broad range of indications and, within a drug class, is often facilitated by the availability of multiple drugs considered equivalent. Such treatment changes are often considered to improve outcomes via better efficacy or fewer side effects, or to be more cost-effective. Drug switching can be both appropriate and beneficial for several reasons; however, switching can also be associated with negative consequences. Aim To consider the impact of switching in two situations: the use of statins as a well-studied example of within-class drug switching, and gonadotropin-releasing hormone (GnRH)-targeting drug switching as an example of cross-class switching. Results With the example of statins, within-class switching may be justified to reduce side effects, although the decision to switch is often also driven by the lower cost of generic formulations. With the example of GnRH agonists/antagonists, switching often occurs without the realisation that these drugs belong to different classes, with potential clinical implications. Conclusion Lessons emerging from these examples will help inform healthcare practitioners who may be considering switching drug prescriptions. |
| Databáze: | OpenAIRE |
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