Vitamin D is Not a Protective Factor in ALS
| Autor: | Blandine Madji Hounoum, Stéphane Beltran, Philippe Corcia, Christian R. Andres, Paul H. Gordon, Franck Patin, Hélène Blasco, François Maillot, Diane Dufour-Rainfray |
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| Rok vydání: | 2015 |
| Předmět: |
Male
medicine.medical_specialty Protective factor Kaplan-Meier Estimate Disease Gastroenterology vitamin D deficiency Body Mass Index Negatively associated Physiology (medical) Internal medicine Vitamin D and neurology Humans Medicine Pharmacology (medical) In patient Prospective Studies Vitamin D Aged Proportional Hazards Models Pharmacology business.industry Amyotrophic Lateral Sclerosis Original Articles Middle Aged Protective Factors Prognosis medicine.disease Surgery Psychiatry and Mental health Cohort Disease Progression Female business Body mass index |
| Zdroj: | CNS Neuroscience & Therapeutics. 21:651-656 |
| ISSN: | 1755-5930 |
| DOI: | 10.1111/cns.12423 |
| Popis: | Summary Aims Vitamin D deficiency has been associated with poorer prognosis in ALS. Better understanding of the role of vitamin D in ALS is needed to determine whether trials of systematic supplementation are justified. Our aim was to report vitamin D levels during the course of ALS and to evaluate its relationship with clinical parameters at diagnosis and with disease progression. Methods We prospectively collected vitamin D serum concentrations from 125 consecutive ALS patients. Cox proportional hazard models analyzed the relationship between vitamin D concentrations, clinical parameters, and survival. Results The mean vitamin D concentration was below our laboratory's lower limit of normal (P |
| Databáze: | OpenAIRE |
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