Nitric oxide modulates articular sensory discharge and responsiveness to bradykinin in normal and arthritic rats in vivo
| Autor: | Daniel S. McQueen, Aziz Asghar, David C. Kelly, C.G. Marr |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Male
medicine.medical_specialty Inflammatory arthritis Bradykinin Arginine Nitric oxide chemistry.chemical_compound Nerve Fibers In vivo Internal medicine medicine Animals Enzyme Inhibitors Rats Wistar Afferent Pathways biology General Neuroscience medicine.disease Arthritis Experimental Rats Nitric oxide synthase Electrophysiology NG-Nitroarginine Methyl Ester Nociception Endocrinology chemistry Enzyme inhibitor biology.protein Nitric Oxide Synthase Ankle Joint Joint Capsule |
| Zdroj: | Neuroreport. 12:121-125 |
| ISSN: | 0959-4965 |
| DOI: | 10.1097/00001756-200101220-00032 |
| Popis: | Nitric oxide is implicated in peripheral nociceptive processing. This study determined the effects of the nitric oxide synthase inhibitor, L-NAME, on neural discharge from articular C-fibre afferents innervating normal and arthritic ankle joints in anaesthetized rats. Intra-arterial injection of L-NAME (10-20 mg kg(-1)) increased neural discharge in normal and arthritic ankle joints, whereas D-NAME (30 mg kg(-1)) had no effect. The excitation induced by L-NAME (20 mg kg(-1)) was reduced by co-injecting the nitric oxide precursor, L-arginine (50 mg kg(-1)). L-NAME (20 mg kg(-1)) also enhanced responsiveness to bradykinin (10 microg) but only in arthritic rats, whereas L-arginine (50 mg kg(-1)) reduced the excitation by bradykinin (30 microg) in both groups. These results provide evidence that nitric oxide modulates articular C-fibre activity and reduces responsiveness to bradykinin. |
| Databáze: | OpenAIRE |
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