Relationships of SLC2A4, RBP4, PCK1, and PI3K Gene Polymorphisms with Gestational Diabetes Mellitus in a Chinese Population

Autor: Shujuan Ma, Zhengwen Tian, Hui-ling Liang, Shimin Hu, Junxia Yan, Hongzhuan Tan, Xun Li, Mengshi Chen
Rok vydání: 2019
Předmět:
Blood Glucose
0301 basic medicine
endocrine system diseases
medicine.medical_treatment
lcsh:Medicine
Type 2 diabetes
Phosphatidylinositol 3-Kinases
0302 clinical medicine
Pregnancy
Insulin
Glucose Transporter Type 4
Intracellular Signaling Peptides and Proteins
General Medicine
Gestational diabetes
Female
Phosphoenolpyruvate Carboxykinase (GTP)
Retinol binding
Research Article
Signal Transduction
Adult
medicine.medical_specialty
Article Subject
Genotype
030209 endocrinology & metabolism
Polymorphism
Single Nucleotide
General Biochemistry
Genetics and Molecular Biology
03 medical and health sciences
Insulin resistance
Asian People
Internal medicine
Diabetes mellitus
medicine
Humans
Genetic Predisposition to Disease
General Immunology and Microbiology
Multifactor dimensionality reduction
business.industry
lcsh:R
nutritional and metabolic diseases
Type 2 Diabetes Mellitus
medicine.disease
Diabetes
Gestational
030104 developmental biology
Endocrinology
Diabetes Mellitus
Type 2
Case-Control Studies
Insulin Resistance
business
Retinol-Binding Proteins
Plasma
Zdroj: BioMed Research International
BioMed Research International, Vol 2019 (2019)
ISSN: 2314-6141
2314-6133
Popis: Background. Solute carrier family 2 member 4- (SLC2A4-) retinol binding protein-4- (RBP4-) phosphoenolpyruvate carboxykinase 1 (PCK1)/phosphoinositide 3-kinase (PI3K) is an adipocyte derived “signalling pathway” that may contribute to the pathogenesis of type 2 diabetes mellitus (T2DM). We explored whether single nucleotide polymorphisms (SNPs) of these “signalling pathway” genes are associated with gestational diabetes mellitus (GDM). Methods. Case-control studies were conducted to compare GDM and control groups. A total of 334 cases and 367 controls were recruited. Seventeen candidate SNPs of the pathway were selected. Chi-square tests, logistic regression, and linear regression were used to estimate the relationships of SNPs with GDM risk and oral glucose tolerance test (OGTT), fasting insulin, and homeostasis model assessment of insulin resistance (HOMA-IR) levels. Model-based multifactor dimensionality reduction was used to estimate the adjusted interactions between genes. Regression and interaction analyses were adjusted by maternal age, prepregnancy BMI, and weekly BMI growth. The Bonferroni correction was applied for multiple comparisons. Results. RBP4 rs7091052 was significantly associated with GDM risk. SLC2A4 rs5435, RBP4 rs7091052, PCK1 rs1042531 and rs2236745, and PIK3R1 (coding gene of the PI3K P85 subunit) rs34309 were associated with OGTT, fasting insulin, and HOMA-IR levels in the linear regression analysis. The gene-gene interaction analysis showed that, compared with pregnant women with other genotype combinations, women with SLC2A4 rs5435 (CC/CT), RBP4 rs7091052 (CC), PCK1 rs1042531 (TT/TG) and rs2236745 (TT), and PIK3R1 rs34309 (AA) had lower GDM risk. Conclusion. SLC2A4, RBP4, PCK1, and PIK3R1 genes may be involved in the pathogenesis of GDM.
Databáze: OpenAIRE
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