Existence of a Strong Correlation of Biomarkers and miRNA in Females with Metabolic Syndrome and Obesity in a Population of West Virginia
| Autor: | Krithika Srikanthan, Dana Sharma, Nader G. Abraham, Joseph I. Shapiro, Kathleen O'Hanlon, Rebecca L. Klug, Alexandra Nichols, Nitin Puri, Perrine Goguet-Rubio, Komal Sodhi, Vishal Hari Lakhani |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Adult Leptin medicine.medical_specialty Population serum biomarkers Physiology Disease Biology 03 medical and health sciences Risk Factors Internal medicine medicine Humans Obesity education Interleukin 6 West Virginia Metabolic Syndrome education.field_of_study Adiponectin microRNA Interleukin-6 Type 2 Diabetes Mellitus General Medicine medicine.disease 3. Good health MicroRNAs 030104 developmental biology Endocrinology Diabetes Mellitus Type 2 Cardiovascular Diseases biology.protein Female Metabolic syndrome Biomarkers Research Paper |
| Zdroj: | International Journal of Medical Sciences |
| ISSN: | 1449-1907 |
| Popis: | Objectives: Metabolic syndrome causes complications like cardiovascular disease and type 2 diabetes mellitus (T2DM). As metabolic syndrome develops, altered levels of cytokines and microRNAs (miRNA) are measurable in the circulation. We aimed to construct a panel detecting abnormal levels of cytokines and miRNAs in patients at risk for metabolic syndrome. Methods: Participants included 54 patients from a Family Medicine Clinic at Marshall University School of Medicine, in groups of: Control, Obese, and Metabolic Syndrome (MetS). Results: Serum levels of leptin, adiponectin, leptin: adiponectin ratio, IL-6, six miRNAs (320a, 197-3p, 23-3p, 221-3p, 27a-3p, and 130a-3p), were measured. Among the three groups, leptin, and leptin: adiponectin ratio, and IL-6 levels were highest in MetS, and levels in Obese were greater than Control (p>0.05). Adiponectin levels were lower in Obese compared to Control, but lowest in MetS (p0.05). Conclusion: Our results support the clinical application of biomarkers in diagnosing early stage MetS, which will enable attenuation of disease progression before onset of irreversible complications. Since West Virginians are high-risk for developing MetS, our biomarker panel could reduce the disease burden on our population. |
| Databáze: | OpenAIRE |
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