The Th17/Treg cell balance: crosstalk among the immune system, bone and microbes in periodontitis

Autor: Jianwen Deng, Chunting Lu, Qingtong Zhao, Kexiao Chen, Shuyuan Ma, Zejian Li
Rok vydání: 2021
Předmět:
Zdroj: Journal of periodontal researchREFERENCES. 57(2)
ISSN: 1600-0765
Popis: Periodontopathic bacteria constantly stimulate the host, which causes an immune response, leading to host-induced periodontal tissue damage. The complex interaction and imbalance between Th17 and Treg cells may be critical in the pathogenesis of periodontitis. Furthermore, the RANKL/RANK/OPG system plays a significant role in periodontitis bone metabolism, and its relationship with the Th17/Treg cell imbalance may be a bridge between periodontal bone metabolism and the immune system. This article reviews the literature related to the Th17/Treg cell imbalance mediated by pathogenic periodontal microbes, and its mechanism involving RANKL/RANK/OPG in periodontitis bone metabolism, in an effort to provide new ideas for the study of the immunopathological mechanism of periodontitis.
Databáze: OpenAIRE