Dynamic imaging for CAR-T-cell therapy
| Autor: | Sophie Papa, Nia Emami-Shahri |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Sodium-iodide symporter Diagnostic Imaging T-Lymphocytes Receptors Antigen T-Cell Biochemistry CD19 03 medical and health sciences Medicine Animals Humans Tomography Emission-Computed Single-Photon Reporter gene PET-CT medicine.diagnostic_test biology Somatostatin receptor business.industry Deoxycytidine kinase Adoptive Transfer 030104 developmental biology Thymidine kinase Positron emission tomography Cancer research biology.protein business Tomography X-Ray Computed |
| Zdroj: | Biochemical Society transactions. 44(2) |
| ISSN: | 1470-8752 |
| Popis: | Chimaeric antigen receptor (CAR) therapy is entering the mainstream for the treatment of CD19+ cancers. As is does we learn more about resistance to therapy and the role, risks and management of toxicity. In solid tumour CAR therapy research the route to the clinic is less smooth with a wealth of challenges facing translating this, potentially hugely valuable, therapeutic option for patients. As we strive to understand our successes, and navigate the challenges, having a clear understanding of how adoptively transferred CAR-T-cells behave in vivo and in human trials is invaluable. Harnessing reporter gene imaging to enable detection and tracking of small numbers of CAR-T-cells after adoptive transfer is one way by which we can accomplish this. The compatibility of certain reporter gene systems with tracers available routinely in the clinic makes this approach highly useful for future appraisal of CAR-T-cell success in humans. * CT, : computed tomography; CAR, : chimaeric antigen receptor; D2R, : dopamine type 2-receptor; hdCKDM, : human deoxycytidine kinase double mutant; hNET, : human noradrenaline transporter gene; hNIS, : human sodium iodide symporter; hSSTr2, : human somatostatin receptor subtype 2; HSV-tk, : herpes simplex virus thymidine kinase; hΔTK2DM, : truncated and mutated human mitochondrial thymidine kinase 2; MIBG, : metaiodobenzylguanidine; PET, : positron emission tomography; SPECT, : single photon emission computed tomography |
| Databáze: | OpenAIRE |
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