Coexistence of regulatory B cells and regulatory T cells in tumor-infiltrating lymphocyte aggregates is a prognostic factor in patients with breast cancer
| Autor: | Masahiro Sakakibara, Ayako Nakagawa, Takahito Masuda, Yukio Nakatani, Emi Ishigami, Junta Sakakibara, Takeshi Nagashima, Takafumi Sangai, Shouko Hayama, Hiroshi Fujimoto, Masayuki Otsuka |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Regulatory T cell Regulatory B cells Breast Neoplasms chemical and pharmacologic phenomena Kaplan-Meier Estimate T-Lymphocytes Regulatory Immune tolerance Metastasis 03 medical and health sciences Lymphocytes Tumor-Infiltrating 0302 clinical medicine Breast cancer medicine Humans Pharmacology (medical) Radiology Nuclear Medicine and imaging IL-2 receptor B-Lymphocytes Regulatory Tumor-infiltrating lymphocytes business.industry Carcinoma Ductal Breast Interleukin-2 Receptor alpha Subunit Cancer hemic and immune systems General Medicine Prognosis medicine.disease Immunohistochemistry Interleukin-10 Carcinoma Intraductal Noninfiltrating 030104 developmental biology medicine.anatomical_structure Oncology 030220 oncology & carcinogenesis Cancer research Female business |
| Zdroj: | Breast Cancer. 26:180-189 |
| ISSN: | 1880-4233 1340-6868 |
| Popis: | Tumors can acquire tolerance to tumor immunity and develop enhanced proliferation. Regulatory B cells (Bregs), whose role in immune tolerance is similar to that of regulatory T cells (Tregs), appear to be involved in tumor immunity. Recently, Bregs were found to induce Tregs against tumor immunity. However, the platform for the coexistence of Bregs and Tregs in cancer patients and its clinical significance remain unclear; thus, they were evaluated in breast cancer patients. In 489 breast cancer patients, CD25- and IL10-positive Bregs and Foxp3-positive Tregs were immunohistochemically evaluated in tumor-infiltrating lymphocyte aggregates (TIL aggregates) that consisted of CD19-positive B-cell follicles and CD3-positive T-cell parafollicles. Then the correlations of the localization and existence of these cells with metastasis-free survival (MFS) were evaluated in breast cancer patients. TIL aggregates were observed in marginal regions of tumors in breast cancer patients. In the TIL aggregates, the existence of Bregs was closely related to that of Tregs (p |
| Databáze: | OpenAIRE |
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