Histological regression of gastrointestinal peritoneal metastases after systemic chemotherapy
| Autor: | Nicolas Demartines, Martin Hübner, Jean-Luc Barras, Hugo Teixeira Farinha, Christine Sempoux, Laura Toussaint |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
medicine.medical_treatment PIPAC Specialties of internal medicine chemotherapy Tumor response Gastroenterology 03 medical and health sciences peritoneal regression grading system (PRGS) 0302 clinical medicine Internal medicine Internal Medicine medicine Chemotherapy business.industry Systemic chemotherapy Regression RC581-951 Quartile peritoneal metastasis 030220 oncology & carcinogenesis Cohort Conventional PCI Medicine 030211 gastroenterology & hepatology business Research Article Cohort study |
| Zdroj: | Pleura and peritoneum, vol. 6, no. 3, pp. 113-119 Pleura and Peritoneum Pleura and Peritoneum, Vol 6, Iss 3, Pp 113-119 (2021) |
| Popis: | Objectives Peritoneal metastases (PM) are relatively resistant to systemic chemotherapy, and data on histological response to therapy is rare. The aim of this study was to quantify the treatment response of PM after systemic chemotherapy. Methods Retrospective monocentric cohort study of 47 consecutive patients with PM from gastrointestinal origin undergoing surgery (cytoreduction: CRS + Hyperthermic IntraPEritoneal Chemotherapy [HIPEC] or Pressurized IntraPeritoneal Aerosol Chemotherapy [PIPAC]) after prior systemic chemotherapy from 1.2015 to 3.2019. Tumor response was assessed using the 4-scale Peritoneal Regression Grading System (PRGS) (4: vital tumor to 1: complete response). Results Patients had a median of 2 (range: 1–7) lines and 10 (3–39) cycles of prior systemic chemotherapy. A median of four biopsies (range: 3–8) was taken with a total of 196 analyzed specimens. Twenty-four biopsies (12%) showed no histological regression (PRGS4), while PRGS 3, two and one were diagnosed in 37 (19%), 39 (20%), and 69 (49%) specimens, respectively. A significant heterogeneity was found between peritoneal biopsies in 51% patients. PRGS correlated strongly with peritoneal spread (PCI, p Conclusions PRGS is an objective too to describe histological response of PM of GI origin after systemic chemotherapy. This response differs significantly between patients, allowing to distinguish between chemosensitive and chemoresistant tumors. |
| Databáze: | OpenAIRE |
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