The peripheral and central mechanisms underlying itch
| Autor: | Jasmin Sang Hyun Han, Kyeong Ho Lee, Ju Won Bang, Hyosang Lee, Jae Seung Lee |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Protease-activated receptor Central nervous system Sensory system Itch Biochemistry Endothelin Afferent Neurons Receptors G-Protein-Coupled Primary sensory neurons Primary afferents 03 medical and health sciences 0302 clinical medicine immune system diseases Ganglia Spinal BAM8-22 parasitic diseases Sensation MrgprA3 otorhinolaryngologic diseases medicine Animals Humans skin and connective tissue diseases Chronic itch Molecular Biology Cowhage Pruritus Brain Chloroquine General Medicine Anatomy Magnetic Resonance Imaging Neuronal pathway eye diseases Invited Mini Review Pruritogen Peripheral 030104 developmental biology medicine.anatomical_structure Spinal Cord Positron-Emission Tomography MrgprC11 Neuroscience 030217 neurology & neurosurgery Histamine |
| Zdroj: | BMB Reports |
| ISSN: | 1976-6696 |
| DOI: | 10.5483/bmbrep.2016.49.9.108 |
| Popis: | Itch is one of the most distressing sensations that substantially impair quality of life. It is a cardinal symptom of many skin diseases and is also caused by a variety of systemic disorders. Unfortunately, currently available itch medications are ineffective in many chronic itch conditions, and they often cause undesirable side effects. To develop novel therapeutic strategies, it is essential to identify primary afferent neurons that selectively respond to itch mediators as well as the central nervous system components that process the sensation of itch and initiate behavioral responses. This review summarizes recent progress in the study of itch, focusing on itch-selective receptors, signaling molecules, neuronal pathways from the primary sensory neurons to the brain, and potential decoding mechanisms based on which itch is distinguished from pain. [BMB Reports 2016; 49(9): 474-487]. |
| Databáze: | OpenAIRE |
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