Surgical outcomes of repeat trabeculectomy augmented with high dose mitomycin C

Autor: Sujani Shroff, Ashok Vardhan, Sharmila Rajendrababu, SR Krishnadas, Sangeeta Vivek Patil, Mohammed Sithiq Uduman
Rok vydání: 2019
Předmět:
Intraocular pressure
Time Factors
Visual acuity
genetic structures
Failed trabeculectomy
medicine.medical_treatment
Intraoperative Period
Postoperative Complications
0302 clinical medicine
lcsh:Ophthalmology
Trabeculectomy
Statistical analysis
Child
repeat trabeculectomy
mitomycin C
Aged
80 and over
Antibiotics
Antineoplastic
Outcome measures
Middle Aged
Treatment Outcome
Child
Preschool
Original Article
Injections
Intraocular
medicine.symptom
Adult
medicine.medical_specialty
Adolescent
Mitomycin
Individual risk
Young Adult
03 medical and health sciences
medicine
Humans
Risk factor
Intraocular Pressure
Aged
Retrospective Studies
Dose-Response Relationship
Drug
business.industry
Mitomycin C
Glaucoma
eye diseases
Surgery
Ophthalmology
lcsh:RE1-994
030221 ophthalmology & optometry
sense organs
business
030217 neurology & neurosurgery
Follow-Up Studies
Zdroj: Indian Journal of Ophthalmology
Indian Journal of Ophthalmology, Vol 67, Iss 1, Pp 95-100 (2019)
ISSN: 0301-4738
DOI: 10.4103/ijo.ijo_682_18
Popis: Purpose: To evaluate the surgical outcomes of repeat trabeculectomy augmented with risk factor adjusted mitomycin C (MMC) exposure in eyes with previous failed trabeculectomy. Methods: Case records of 38 eyes of 37 patients with previous failed filter who underwent repeat trabeculectomy with MMC were reviewed retrospectively. Main outcome measures were best-corrected visual acuity (BCVA), intraocular pressure (IOP) reduction, requirement of anti-glaucoma medications, postoperative complications, and surgical success (defined as IOP of ≤21 mmHg and >5 mmHg along with 20% reduction from preoperative IOP with or without adjuvant medications) at 1-year postoperatively. Statistical analysis was done using the STATA 14.1 (Texas, USA). Results: Patient's mean age was 46.41 (±20.43) years and the mean preoperative IOP was 32.73 (±9.26) mmHg which reduced to 16.22 (±7.08) mmHg postoperatively at 12 months (P < 0.001). Mean number of anti-glaucoma medications reduced from 2.76 (±0.83) preoperatively to 1.89 (±0.95) postoperatively (P < 0.001). Surgical success was observed in 81.1% at 1 year (n = 30). Eyes that received MMC >3 min had a postoperative mean IOP of 12.50 (±3.23) mmHg compared to 23.08 (±7.19) mmHg with MMC 3 min (P = 0.033). Conclusion: Repeat trabeculectomy with MMC, used in higher concentration and exposure time altered according to individual risk factor plays a crucial role in the success and hence it could be considered as a viable option before planning a tube surgery.
Databáze: OpenAIRE
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