Enhanced pretreatment CD25 expression on peripheral blood CD4+ T cell predicts shortened survival in acute myeloid leukemia patients receiving induction chemotherapy
| Autor: | Małgorzata Rusak, Urszula Radzikowska, Lothar R. Pilz, Izabela Łapuć, Milena Dąbrowska, Marcin Moniuszko, Łukasz Bołkun, Ewa Łuksza, Janusz Kloczko, Anna Bodzenta-Łukaszyk, Andrzej Eljaszewicz |
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| Rok vydání: | 2015 |
| Předmět: |
0301 basic medicine
Oncology Adult CD4-Positive T-Lymphocytes Male medicine.medical_specialty Alpha (ethology) Biology Flow cytometry 03 medical and health sciences 0302 clinical medicine Predictive Value of Tests Internal medicine medicine Humans IL-2 receptor Interleukin-7 receptor Receptor Survival rate Aged Pharmacology medicine.diagnostic_test Interleukin-2 Receptor alpha Subunit Myeloid leukemia Induction chemotherapy General Medicine Induction Chemotherapy Middle Aged Flow Cytometry Gene Expression Regulation Neoplastic Survival Rate Leukemia Myeloid Acute 030104 developmental biology 030220 oncology & carcinogenesis Immunology Leukocytes Mononuclear Female |
| Zdroj: | Pharmacological reports : PR. 68(1) |
| ISSN: | 2299-5684 |
| Popis: | Background Recently, identification of CD25 (interleukin-2 receptor alpha) expression on leukemic blasts was correlated to early treatment failure and unfavorable outcome in acute myeloid leukemia (AML) patients. Here we wished to determine whether quantification of CD25 on peripheral blood CD4+ T cells could improve prognostication in newly diagnosed AML patients. Methods The mean fluorescence intensity (MFI) of CD25 expression and frequencies of peripheral blood CD4+ T cells with varying levels of CD25 and CD127 expression were assessed by flow cytometry in all studied individuals. Results Using univariate (unadjusted) and multivariate (adjusted) analyses we demonstrated that detection of high pretreatment CD25 expression on circulating CD4+ T cells was associated with significantly decreased survival rate of AML patients subjected to standard induction chemotherapy. These associations held true for both entire group of analyzed AML patients and different subgroups of patients identified by presence or absence of favorable and adverse molecular prognostic factors. Conclusions Our data indicate that quantification of CD25 expression on peripheral blood CD4+ T cells could become a novel, easily accessible method of shortened survival prognostication of AML patients subjected to standard cytotoxic therapy. |
| Databáze: | OpenAIRE |
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