Metabolism of Triaryl Phosphates in Rodents

Autor:	E. G. L. Simons, C. Veeger, J. B. J. Rebel, D. K. Myers, A. Kemp
Rok vydání:	1955
Předmět:	Multidisciplinary Biochemical Phenomena Chemistry Metabolism Inhibitory postsynaptic potential Phosphate In vitro Phosphates Tritolyl Phosphates chemistry.chemical_compound Biochemistry In vivo Paralysis medicine medicine.symptom Incubation
Zdroj:	Nature. 176:259-260
ISSN:	1476-4687 0028-0836
DOI:	10.1038/176259a0
Popis:	CONSIDERABLE interest is attached to the metabolism of the compound tri-o-cresyl phosphate, which has been shown to inhibit various esterases in vivo and which is capable of producing demyelination and paralysis in certain species of animals1. Pure tri-o-cresyl phosphate exhibits little inhibitory activity against esterases in vitro 2,3 and the compound appears to be converted into an active inhibitor in the animal; this conversion can also be effected by incubation with liver slices in vitro 3.
Databáze:	OpenAIRE
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