Effect of the native polysaccharide of cashew-nut tree gum exudate on murine peritoneal macrophage modulatory activities
| Autor: | Fernanda Bovo, Juliana Bello Baron Maurer, Antony Bacic, R.M. Lenzi, F.R. Stevan-Hancke, Luciano Henrique Campestrini, Filomena Pettolino, A. Soldera-Silva, M. Seyfried, Fábio Tomio Yamassaki, Selma Faria Zawadzki-Baggio |
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| Rok vydání: | 2014 |
| Předmět: |
Exudate
Antioxidant Polymers and Plastics Lipopolysaccharide medicine.drug_class medicine.medical_treatment Biology Polysaccharide Nitric Oxide Anti-inflammatory Nitric oxide Microbiology chemistry.chemical_compound Interferon-gamma Mice Mucoproteins Plant Gums Materials Chemistry medicine Macrophage Animals Anacardium Cells Cultured Plant Proteins chemistry.chemical_classification Organic Chemistry Interleukin Interleukin-10 chemistry Biochemistry Macrophages Peritoneal medicine.symptom |
| Zdroj: | Carbohydrate polymers. 125 |
| ISSN: | 1879-1344 |
| Popis: | The native polysaccharide of cashew-nut tree gum exudate (CNTG) and its arabinogalactan-protein component (CNTG-AGP) were tested by using immuno-stimulant and anti-inflammatory in vitro assays of murine peritoneal macrophage activities. In the assay for immuno-stimulant activity (without previous treatment with lipopolysaccharide; LPS), CNTG increased the production of interleukin (IL)-10 and both CNTG and CNTG-AGP decreased the concentrations of IL6. When the macrophages were incubated in the presence of LPS and CNTG a decrease in the levels of nitric oxide (NO(·)) and IFN-γ was observed. The results could explain the popular use of CNTG as an anti-inflammatory. In addition, CNTG is the main component of the cashew-nut tree gum exudate, which has been considered a versatile polymer with potential pharmaceutical and food industry applications. These data may contribute to the study of the immunomodulation activity of plant polysaccharides, as well as encourage future experiments in the field of cashew-nut tree gum exudate applications. |
| Databáze: | OpenAIRE |
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