Brain region-specific effects of immobilization stress on cholinesterases in mice
| Autor: | Paulina Valuskova, Jaromir Myslivecek, Katarina Ondicova, Vladimir Farar, Katerina Janisova, Boris Mravec, Richard Kvetnansky |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Male Restraint Physical medicine.medical_specialty Physiology Aché Corticotropin-Releasing Hormone Functional Laterality 03 medical and health sciences Behavioral Neuroscience chemistry.chemical_compound Mice 0302 clinical medicine Stress Physiological Internal medicine medicine Animals Butyrylcholinesterase Cholinesterase Hormone response element Mice Knockout biology Endocrine and Autonomic Systems Wild type Brain Acetylcholinesterase language.human_language Psychiatry and Mental health 030104 developmental biology Neuropsychology and Physiological Psychology Endocrinology chemistry language biology.protein hormones hormone substitutes and hormone antagonists 030217 neurology & neurosurgery Acetylcholine Glucocorticoid Stress Psychological medicine.drug |
| Zdroj: | Stress (Amsterdam, Netherlands). 20(1) |
| ISSN: | 1607-8888 |
| Popis: | Brain acetylcholinesterase (AChE) variant AChER expression increases with acute stress, and this persists for an extended period, although the timing, strain and laterality differences, have not been explored previously. Acute stress transiently increases acetylcholine release, which in turn may increase activity of cholinesterases. Also the AChE gene contains a glucocorticoid response element (GRE), and stress-inducible AChE transcription and activity changes are linked to increased glucocorticoid levels. Corticotropin-releasing hormone knockout (CRH-KO) mice have basal glucocorticoid levels similar to wild type (WT) mice, but much lower levels during stress. Hence we hypothesized that CRH is important for the cholinesterase stress responses, including butyrylcholinesterase (BChE). We used immobilization stress, acute (30 or 120 min) and repeated (120 min daily × 7) in 48 male mice (24 WT and 24 CRH-KO) and determined AChER, AChE and BChE mRNA expression and AChE and BChE activities in left and r... |
| Databáze: | OpenAIRE |
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