Thyroid Cancer and Benign Nodules After ExposureIn Uteroto Fallout From Chernobyl

Autor: Galyna Zamotayeva, Viktoria Klochkova, Mykola Tronko, Maureen Hatch, Tatiana Bogdanova, Victor Shpak, Mark P. Little, Kiyohiko Mabuchi, Elizabeth K. Cahoon, Vladimir Drozdovitch, Evgeniy Shelkovoy, Galyna Terekhova, Elena Bolshova, Alina V. Brenner
Rok vydání: 2018
Předmět:
Adult
Male
Radioactive Fallout
0301 basic medicine
Thyroid nodules
medicine.medical_specialty
Neoplasms
Radiation-Induced
Adolescent
Republic of Belarus
Endocrinology
Diabetes and Metabolism
Clinical Biochemistry
Risk Assessment
Biochemistry
Gastroenterology
Iodine Radioisotopes
03 medical and health sciences
0302 clinical medicine
Endocrinology
Pregnancy
Internal medicine
medicine
Humans
Mass Screening
Thyroid Neoplasms
Thyroid Nodule
Child
Thyroid cancer
Clinical Research Articles
Mass screening
Ultrasonography
business.industry
Biochemistry (medical)
Thyroid
Dose-Response Relationship
Radiation
Nodule (medicine)
medicine.disease
030104 developmental biology
medicine.anatomical_structure
Chernobyl Nuclear Accident
In utero
Child
Preschool
Prenatal Exposure Delayed Effects
030220 oncology & carcinogenesis
Cohort
Female
medicine.symptom
business
Risk assessment
Zdroj: The Journal of Clinical Endocrinology & Metabolism. 104:41-48
ISSN: 1945-7197
0021-972X
Popis: BACKGROUND: Children and adolescents exposed to radioactive iodine-131 (I-131) in fallout from the 1986 Chernobyl nuclear accident appear to be at increased risk of thyroid cancer and benign thyroid nodules. The prenatal period is also considered radiosensitive, and the fetal thyroid can absorb I-131 from the maternal circulation. OBJECTIVES: We aimed to estimate the risk of malignant and benign thyroid nodules in individuals exposed prenatally. METHODS: We studied a cohort of 2582 subjects in Ukraine with estimates of I-131 prenatal thyroid dose (mean = 72.6 mGy), who underwent two standardized thyroid screening examinations. To evaluate the dose-response relationship, we estimated the excess OR (EOR) using logistic regression. RESULTS: Based on a combined total of eight cases diagnosed at screenings from 2003 to 2006 and 2012 to 2015, we found a markedly elevated, albeit not statistically significant, dose-related risk of thyroid cancer (EOR/Gy = 3.91, 95% CI: –1.49, 65.66). At cycle 2 (n = 1,786), there was a strong and significant association between I-131 thyroid dose and screen-detected large benign nodules (≥10 mm) (EOR/Gy = 4.19, 95% CI: 0.68, 11.62; P = 0.009), but no significant increase in risk for small nodules (
Databáze: OpenAIRE
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