Sensory overamplification in layer 5 auditory corticofugal projection neurons following cochlear nerve synaptic damage
| Autor: | Ross S. Williamson, Meenakshi M. Asokan, Kenneth E. Hancock, Daniel B. Polley |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Male
0301 basic medicine Inferior colliculus Auditory Pathways Sensory processing medicine.medical_treatment Science Thalamus General Physics and Astronomy Sensory system Biology Auditory cortex Article General Biochemistry Genetics and Molecular Biology Adenoviridae Mice Tinnitus 03 medical and health sciences 0302 clinical medicine Neuroplasticity medicine Animals Axon lcsh:Science Cochlear Nerve Auditory Cortex Neuronal Plasticity Multidisciplinary Cochlear nerve General Chemistry Amygdala Publisher Correction Corpus Striatum Inferior Colliculi Mice Inbred C57BL Hyperacusis 030104 developmental biology medicine.anatomical_structure Acoustic Stimulation nervous system Mice Inbred CBA Female lcsh:Q Noise Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Nature Communications, Vol 9, Iss 1, Pp 1-10 (2018) Nature Communications |
| ISSN: | 2041-1723 |
| Popis: | Layer 5 (L5) cortical projection neurons innervate far-ranging brain areas to coordinate integrative sensory processing and adaptive behaviors. Here, we characterize a plasticity in L5 auditory cortex (ACtx) neurons that innervate the inferior colliculus (IC), thalamus, lateral amygdala and striatum. We track daily changes in sound processing using chronic widefield calcium imaging of L5 axon terminals on the dorsal cap of the IC in awake, adult mice. Sound level growth functions at the level of the auditory nerve and corticocollicular axon terminals are both strongly depressed hours after noise-induced damage of cochlear afferent synapses. Corticocollicular response gain rebounded above baseline levels by the following day and remained elevated for several weeks despite a persistent reduction in auditory nerve input. Sustained potentiation of excitatory ACtx projection neurons that innervate multiple limbic and subcortical auditory centers may underlie hyperexcitability and aberrant functional coupling of distributed brain networks in tinnitus and hyperacusis. Deep layer auditory cortex neurons project to a number of limbic and subcortical auditory structures. Here, the authors show how these corticofugal projections adjust response gain following noise-induced cochlear damage. |
| Databáze: | OpenAIRE |
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