DNA cleavage, antibacterial, antifungal and anthelmintic studies of Co(II), Ni(II) and Cu(II) complexes of coumarin Schiff bases: synthesis and spectral approach
| Autor: | Prema S. Badami, Chetan T. Prabhakara, Bhimashankar M. Halasangi, Sangamesh A. Patil, Shivakumar S. Toragalmath |
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| Rok vydání: | 2014 |
| Předmět: |
Spectrophotometry
Infrared Stereochemistry Nitrogen Microbial Sensitivity Tests Ligands Analytical Chemistry Metal chemistry.chemical_compound Deprotonation Anti-Infective Agents Coumarins Nickel Octahedral molecular geometry Molecule Amines DNA Cleavage Instrumentation Spectroscopy Schiff Bases Anthelmintics Schiff base Ligand Temperature Cobalt DNA Carbon-13 NMR Atomic and Molecular Physics and Optics Carbon Spectrometry Fluorescence chemistry Models Chemical Spectrophotometry visual_art visual_art.visual_art_medium Proton NMR Copper Nuclear chemistry Hydrogen |
| Zdroj: | Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy. 137 |
| ISSN: | 1873-3557 |
| Popis: | The metal complexes of Co(II), Ni(II) and Cu(II) have been synthesized from 6-formyl-7,8-dihydroxy-4-methylcoumarin with o-toluidine/3-aminobenzotrifluoride. The synthesized Schiff bases and their metal complexes were structurally characterized based on IR, (1)H NMR, (13)C NMR, UV-visible, ESR, magnetic, thermal, fluorescence, mass and ESI-MS studies. The molar conductance values indicate that complexes are non-electrolytic in nature. Elemental analysis reveals ML2·2H2O [M = Co(II), Ni(II) and Cu(II)] stoichiometry, where 'L' stands for a singly deprotonated ligand. The presence of co-ordinated water molecules were confirmed by thermal studies. The spectroscopic studies suggest the octahedral geometry. Redox behavior of the complexes were confirmed by cyclic voltammetry. All the synthesized compounds were screened for their antibacterial (Escherichia coli, Pseudomonas auregenosa, klebsiella, Proteus, Staphylococcus aureus and salmonella) antifungal (Candida, Aspergillus niger and Rhizopus), anthelmintic (Pheretima posthuma) and DNA cleavage (Calf Thymus DNA) activity. |
| Databáze: | OpenAIRE |
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