Utility of biodegradable plasmonic nanoclusters in photoacoustic imaging
| Autor: | Stanislav Emelianov, Konstantin V Sokolov, Jasmine M. Tam, Soon Joon Yoon, Srivalleesha Mallidi, Avinash K. Murthy, Justina O. Tam, Keith P. Johnston |
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| Jazyk: | angličtina |
| Rok vydání: | 2010 |
| Předmět: |
Materials science
Nanocomposite Phantoms Imaging Nanoparticle Contrast Media Metal Nanoparticles Nanotechnology Acoustics Surface Plasmon Resonance Biodegradable polymer Atomic and Molecular Physics and Optics Imaging phantom Article Nanoclusters Nanocomposites Colloidal gold Feasibility Studies Ultrasonics Gold Molecular imaging Surface plasmon resonance |
| Popis: | Plasmonic metal nanoparticles are used in photoacoustic imaging as contrast agents because of their resonant optical absorption properties in the visible and near-IR regions. However, the nanoparticles could accumulate and result in long-term toxicity in vivo, because they are generally not biodegradable. Recently, biodegradable plasmonic gold nanoclusters, consisting of sub-5 nm primary gold nanoparticles and biodegradable polymer stabilizer, were introduced. In this Letter, we demonstrate the feasibility of biodegradable nanoclusters as a photoacoustic contrast agent. We performed photoacoustic and ultrasound imaging of a tissue-mimicking phantom with inclusions containing nanoclusters at various concentrations. The results indicate that the biodegradable gold nanoclusters can be used as effective contrast agents in photoacoustic imaging. |
| Databáze: | OpenAIRE |
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